In this issue of Cell Chemical Biology, Chatrikhi et al. (2021) identify a small molecule that enhances U2AF2 association with RNA to block pre-mRNA splicing during early stages of spliceosome assembly. This provides a mechanism of splicing inhibition and a molecular tool for elucidating intron recognition and spliceosome assembly.

中文翻译：

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卡在 UUUU 上：新的剪接抑制剂增强 U2AF2-RNA 结合

在本期细胞化学生物学中，Chatrikhi 等人。(2021) 确定了一种小分子，它增强了 U2AF2 与 RNA 的结合，以在剪接体组装的早期阶段阻断前 mRNA 剪接。这提供了剪接抑制机制和阐明内含子识别和剪接体组装的分子工具。