Aim

To identify associations among allelic variants of the genes FTO, ABCA1, ADRB3, and PPARG with anthropometric and biochemical traits, metabolic diseases (obesity, T2D or metabolic syndrome) in an adult population from Northwest Mexico.

Methods

Blood samples were collected from 846 subjects including 266 normal weight subjects, 285 with obesity, and 295 with T2D. Of the 846 persons in the study, 365 presented metabolic syndrome diagnostic criteria. Anthropometric and biochemical traits were recorded and 4 single nucleotide polymorphisms (SNPs): FTO rs9939609 A-allele, ABCA1 rs9282541 A-allele, ADRB3 rs4994 G-allele, and PPARG rs1801282 G-allele were genotyped by real-time PCR.

Results

FTO rs9939609 A-allele was significantly associated with obesity (p: 8.3 × 10⁻⁴), and metabolic syndrome (p: 0.001), but no individual SNPs were significantly associated with T2D. Finally, the cumulative risk of the four SNPs was significantly associated with obesity (p: 1.95 × 10⁻⁴).

Conclusion

Associations in FTO, ABCA, ADRB3, and PPARG SNPs presented in this study with obesity and metabolic syndrome could represent a risk for developing metabolic diseases in Northwest Mexican adult subjects.

中文翻译：

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墨西哥西北部成年人群中 FTO、ABCA1、ADRB3 和 PPARG 变异与肥胖、2 型糖尿病和代谢综合征的关联

目标

确定基因FTO、ABCA1、ADRB3和PPARG的等位基因变异与来自墨西哥西北部的成年人群的人体测量和生化特征、代谢疾病（肥胖、T2D 或代谢综合征）之间的关联。

方法

从 846 名受试者中采集了血液样本，其中包括 266 名正常体重受试者、285 名肥胖受试者和 295 名 T2D 受试者。在研究中的 846 人中，365 人提出了代谢综合征诊断标准。记录人体测量学和生化特征，并通过实时 PCR 对4 个单核苷酸多态性 (SNP)： FTO rs9939609 A 等位基因、ABCA1 rs9282541 A 等位基因、ADRB3 rs4994 G 等位基因和PPARG rs1801282 G 等位基因进行基因分型。

结果

FTO rs9939609 A等位基因与肥胖（p：8.3×10 ^-4）和代谢综合征（p：0.001）显着相关，但没有单个SNP与T2D显着相关。最后，四个 SNP 的累积风险与肥胖显着相关（p：1.95 × 10 ^-4）。

结论

本研究中提出的FTO、ABCA、ADRB3和PPARG SNP 与肥胖和代谢综合征的关联可能代表墨西哥西北部成人受试者患代谢疾病的风险。