The objective of this study was to evaluate the toxic effects of Cr⁶⁺ on bioaccumulation, digestion, immunity, oxidative stress, apoptosis and inflammation-related genes in Channa asiatica. The fish was exposed to waterborne Cr⁶⁺ concentrations (0, 0.5, 1.0 and 2.0 mg/L) for 28 and 56 days. Our results demonstrated that the accumulation of Cr⁶⁺ in tissues increased in a concentration-dependent manner, and the content in tissue was liver > gill > gut > muscle. Meanwhile, Cr⁶⁺ exposure led to a remarkable suppression of digestion, immunity and antioxidant capacity in C. asiatica. Inversely, MDA and PC content were positively correlated with Cr⁶⁺ exposure concentration. Furthermore, the expression of genes went up with the increase of waterborne Cr⁶⁺ concentration. Among them, HSP90, NF-κB and TNF-α have a sharp increase. These results elucidate that waterborne Cr⁶⁺ exposure may induce bioaccumulation, inhibit digestion and immunity, promote oxidative stress and up-regulate the expression of apoptosis and inflammation-related genes in C. asiatica.

本研究的目的是评估Cr ⁶⁺对积雪草生物积累、消化、免疫、氧化应激、细胞凋亡和炎症相关基因的毒性作用。将鱼暴露于水源性 Cr ⁶⁺浓度（^{0、0.5、1.0}和 2.0 毫克/升）中 28 天和 56 天。我们的研究结果表明，组织中Cr ⁶⁺的积累呈浓度依赖性增加，组织中的含量为肝脏>鳃>肠道>肌肉。同时，Cr ⁶⁺暴露导致C. asiatica的消化、免疫和抗氧化能力显着抑制。相反，MDA 和 PC 含量与 Cr ⁶⁺呈正相关暴露浓度。此外，基因的表达随着水性Cr ⁶⁺浓度的增加而增加。其中HSP90、NF-κB和TNF-α有急剧增加。这些结果表明，水性Cr ⁶⁺暴露可诱导积雪草生物积累、抑制消化和免疫、促进氧化应激并上调细胞凋亡和炎症相关基因的表达。