ABSTRACT

Objective

The ectopic expression of Homeobox (HOX) gene cluster-embedded long non-coding RNAs (LncRNAs) have been involved several carcinogenic development and progressions. This meta-analysis aimed to summarize the LncRNAs to validate the functions and the prognostic values in several kinds of cancer.

Methods

The retrospective study was conducted to analyze the association between HOX gene-related LncRNAs and the survival outcomes. Cochran’s Q and I² test were used for calculated heterogeneity, and I² > 50%, P < 0.05 was conformed to the random effect model. Publication bias was indicated by Begg’s and Egger’s test.

Results

Total 15,315 patients extracting from 121 studies focused on assessing the association between LncRNAs and the survival outcomes and 12,110 participants were enrolled to address the clinicopathological features. The results demonstrated that the overexpression of HOX gene cluster-embedded LncRNAs revealed notable association among tumor size (pooled OR = 1.80), lymph node metastasis (LNM) stage (pooled OR = 3.00), tumor node metastasis (TNM) stage (pooled OR = 2.86), histological differentiation (pooled OR = 1.59) and distant metastasis (pooled OR = 2.49). Additionally, the up-regulated LncRNAs predicted a poor prognosis in overall survival (pooled HR = 1.95, 95%CI = 1.86–2.04), and also disclosed worse prognosis among the stratified analysis included HOX clusters, LncRNAs, ethnicity, and tumor classification (pooled HRs >1).

Conclusion

In summary, the findings proved that HOX gene cluster-embedded LncRNAs acted as potential biomarkers for clinical treatment of several tumors and the overexpression might be a candidate hallmark for prognosis outcome.

中文翻译：

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人类癌症中同源框基因簇嵌入 LncRNA 的生存结果和临床病理学分析：系统评价和荟萃分析

摘要

客观的

同源框 (HOX) 基因簇嵌入的长非编码 RNA (LncRNA) 的异位表达涉及几种致癌物的发展和进展。该荟萃分析旨在总结 LncRNA，以验证几种癌症的功能和预后价值。

方法

回顾性研究旨在分析 HOX 基因相关 LncRNA 与生存结果之间的关联。异质性计算采用Cochran's Q和I ^{2检验，I 2}  > 50%，P < 0.05符合随机效应模型。Begg 和 Egger 检验表明发表偏倚。

结果

共有 15,315 名患者从 121 项研究中提取，重点评估 LncRNA 与生存结果之间的关联，并招募了 12,110 名参与者以解决临床病理学特征。结果表明，HOX基因簇嵌入的LncRNA的过表达揭示了肿瘤大小（合并OR = 1.80）、淋巴结转移（LNM）分期（合并OR = 3.00）、肿瘤淋巴结转移（TNM）分期（合并OR）之间的显着关联。 = 2.86)、组织学分化 (合并 OR = 1.59) 和远处转移 (合并 OR = 2.49)。此外，上调的 LncRNA 预测总生存期预后不良（合并 HR = 1.95, 95%CI = 1.86-2.04），并且在包括 HOX 簇、LncRNA、种族和肿瘤分类的分层分析中也显示预后较差。合并 HR > 1)。

结论

总之，研究结果证明 HOX 基因簇嵌入的 LncRNA 作为临床治疗几种肿瘤的潜在生物标志物，过表达可能是预后结果的候选标志。