It is being increasingly acknowledged that immune cells depend on certain metabolic traits to perform their functions and that the extracellular environment can influence cell metabolism and vice versa. Dendritic cell (DC) subsets traffic through highly diverse environments from the bone marrow, where they develop, to the various peripheral tissues, where they differentiate and capture antigens, before they migrate to the lymph node to present antigens and prime T cells. It is plausible that DC subsets modulate their stimulatory abilities in response to unique metabolic programming. The metabolic requirements of DCs are just recently being discovered, and subset- and context-specific metabolic phenotypes in DCs are highly intertwined with DC functions. In this review, we present the current knowledge on the intrinsic and extrinsic determinants of DC metabolism, how they regulate DC function with examples from tumor biology and in interaction with the microbiota, and discuss how this can be applied therapeutically.

人们越来越认识到，免疫细胞依赖于某些代谢特征来发挥其功能，并且细胞外环境可以影响细胞代谢，反之亦然。树突状细胞 (DC) 亚群在高度多样化的环境中运输，从它们发育的骨髓到各种外周组织，在那里它们分化和捕获抗原，然后它们迁移到淋巴结以呈递抗原并引发 T 细胞。DC 亚群根据独特的代谢程序调节其刺激能力是合理的。DC 的代谢需求最近才被发现，DC 中的子集和特定环境的代谢表型与 DC 功能高度交织在一起。在本次审查中，