Melanoma is the deadliest form of skin cancer. Although treatment with targeted therapies and immune checkpoint inhibitors has dramatically improved survival in advanced melanoma, many patients do not benefit from these therapies or relapse after an initial period of response. Thus, future outcomes in these categories of melanoma patients will depend on the identification of novel therapeutic targets and methods to enhance existing targeted therapy and immunotherapy regimens. Ferroptosis is a newly identified form of iron-dependent regulated cell death that is morphologically, biochemically, and genetically distinct from apoptosis, autophagy, pyroptosis, and necroptosis. Dysregulation of ferroptosis has been linked to the development of several forms of cancer. This review examines ferroptosis in the context of melanoma. It presents an overview of ferroptosis biology, summarizes and interprets the current literature, and poses several outstanding questions and areas of future direction.

中文翻译：

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铁死亡在黑色素瘤中的作用

黑色素瘤是最致命的皮肤癌。尽管靶向疗法和免疫检查点抑制剂的治疗显着提高了晚期黑色素瘤的生存率，但许多患者并未从这些疗法中受益或在最初的反应期后复发。因此，这些类别的黑色素瘤患者的未来结果将取决于新的治疗靶点和方法的确定，以增强现有的靶向治疗和免疫治疗方案。铁死亡是一种新发现的铁依赖性调节细胞死亡形式，在形态、生化和遗传上与细胞凋亡、自噬、细胞焦亡和坏死性凋亡不同。铁死亡的失调与几种癌症的发展有关。这篇综述检查了黑色素瘤背景下的铁死亡。