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Enhanced Corrosion Resistance and In Vitro Biocompatibility of Mg-Zn Alloys by Carbonate Apatite Coating
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-08-18 , DOI: 10.1021/acsabm.1c00594 Dinh Ngoc Pham 1 , Sachiko Hiromoto 2 , Tomohiko Yamazaki 3 , Minho O 1 , Equo Kobayashi 1, 4
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-08-18 , DOI: 10.1021/acsabm.1c00594 Dinh Ngoc Pham 1 , Sachiko Hiromoto 2 , Tomohiko Yamazaki 3 , Minho O 1 , Equo Kobayashi 1, 4
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B-type carbonate apatite (CAp) coatings were formed on as-cast and T4-treated Mg-xZn (x = 1, 5, and 7 wt %) alloys containing various sized Zn-rich second phase to improve the corrosion resistance and biocompatibility. The CAp coating grew uniformly on the alloys with a thickness of 1.1–1.3 μm and did not show cracks or pores on 30 μm-sized second-phase particles. The CAp coating retarded corrosion of Mg-Zn substrates for the first 3–5 days in Hanks’ solution. Polarization resistance of the CAp-coated alloys was 10–90 and 1–70 times higher than the uncoated and hydroxyapatite (HAp)-coated alloys, respectively. The corrosion rate of CAp-coated alloys was greatly affected by the substrate alloys once the coatings were partly broken. The CAp-coated alloys showed 40–60 and 25–45% lower 14-day average corrosion rates than the uncoated and HAp-coated alloys, respectively, in the immersion test. The CAp coating significantly enhanced the viability of osteoblastic MC3T3-E1 cells on the Mg-Zn alloys for 72 h compared to the uncoated and HAp-coated alloys. The cell densities on CAp-coated alloys were similar for 72 h regardless of substrate alloys. Therefore, the CAp coating can be a superior coating candidate for corrosion-control and biocompatibility improvement for biodegradable Mg alloys.
中文翻译：
碳酸盐磷灰石涂层增强镁锌合金的耐腐蚀性和体外生物相容性
B 型碳酸盐磷灰石 (CAp) 涂层是在铸态和 T4 处理的 Mg- x Zn ( x= 1、5 和 7 wt %) 合金，含有各种尺寸的富锌第二相，以提高耐腐蚀性和生物相容性。CAp 涂层在厚度为 1.1-1.3 μm 的合金上均匀生长，在 30 μm 大小的第二相颗粒上没有出现裂纹或气孔。CAp 涂层在 Hanks 溶液中的前 3-5 天延缓了 Mg-Zn 基体的腐蚀。CAp 涂层合金的极化电阻分别比未涂层和羟基磷灰石 (HAp) 涂层合金高 10-90 倍和 1-70 倍。一旦涂层被部分破坏，CAp 涂层合金的腐蚀速率会受到基体合金的极大影响。在浸泡试验中，CAp 涂层合金的 14 天平均腐蚀速率分别比未涂层和 HAp 涂层合金低 40-60% 和 25-45%。与未涂层和 HAp 涂层合金相比，CAp 涂层显着增强了 Mg-Zn 合金上成骨细胞 MC3T3-E1 细胞的活力 72 小时。无论基材合金如何，CAp 涂层合金上的细胞密度在 72 小时内都相似。因此，CAp 涂层可以成为可生物降解镁合金腐蚀控制和生物相容性改善的优良涂层候选者。
更新日期：2021-09-20
中文翻译：
碳酸盐磷灰石涂层增强镁锌合金的耐腐蚀性和体外生物相容性
B 型碳酸盐磷灰石 (CAp) 涂层是在铸态和 T4 处理的 Mg- x Zn ( x= 1、5 和 7 wt %) 合金，含有各种尺寸的富锌第二相，以提高耐腐蚀性和生物相容性。CAp 涂层在厚度为 1.1-1.3 μm 的合金上均匀生长，在 30 μm 大小的第二相颗粒上没有出现裂纹或气孔。CAp 涂层在 Hanks 溶液中的前 3-5 天延缓了 Mg-Zn 基体的腐蚀。CAp 涂层合金的极化电阻分别比未涂层和羟基磷灰石 (HAp) 涂层合金高 10-90 倍和 1-70 倍。一旦涂层被部分破坏，CAp 涂层合金的腐蚀速率会受到基体合金的极大影响。在浸泡试验中，CAp 涂层合金的 14 天平均腐蚀速率分别比未涂层和 HAp 涂层合金低 40-60% 和 25-45%。与未涂层和 HAp 涂层合金相比，CAp 涂层显着增强了 Mg-Zn 合金上成骨细胞 MC3T3-E1 细胞的活力 72 小时。无论基材合金如何，CAp 涂层合金上的细胞密度在 72 小时内都相似。因此，CAp 涂层可以成为可生物降解镁合金腐蚀控制和生物相容性改善的优良涂层候选者。
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