Photodynamic Activity of Graphene Oxide/Polyaniline/Manganese Oxide Ternary Composites toward Both Gram-Positive and Gram-Negative Bacteria,ACS Applied Bio Materials

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Photodynamic Activity of Graphene Oxide/Polyaniline/Manganese Oxide Ternary Composites toward Both Gram-Positive and Gram-Negative Bacteria
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-08-17 , DOI: 10.1021/acsabm.1c00677
Gustavo Chata ₁ , Forrest Nichols ₁ , Rene Mercado ₁ , Tufa Assafa ₁ , Glenn L Millhauser ₁ , Chad Saltikov ₂ , Shaowei Chen ₁

Affiliation

Graphene derivatives have been attracting extensive interest as effective antimicrobial agents. In the present study, ternary nanocomposites are prepared based on graphene oxide quantum dots (GOQD), polyaniline (PANI), and manganese oxides. Because of the hydrophilic GOQD and PANI, the resulting GPM nanocomposites are readily dispersible in water and upon photoirradiation at 365 nm exhibit antimicrobial activity toward both Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus epidermidis (S. epidermidis). Notably, the nanocomposite with a high Mn²⁺ and Mn⁴⁺ content is found to be far more active than that with a predominant Mn³⁺ component, although both samples feature a similar elemental composition and average Mn valence state. The bactericidal activity is largely ascribed to the photocatalytic production of hydroxy radicals and photogenerated holes; both are known to exert oxidative stress on bacterial cells. Further antimicrobial contributions may arise from the strong affinity of the nanocomposites to the cell surfaces. These results suggest that the metal valence state may be a critical parameter in the design and engineering of high-performance antimicrobial agents based on metal oxide nanocomposites.

中文翻译：

氧化石墨烯/聚苯胺/氧化锰三元复合材料对革兰氏阳性菌和革兰氏阴性菌的光动力活性

石墨烯衍生物作为有效的抗菌剂已引起广泛关注。在本研究中，基于氧化石墨烯量子点（GOQD）、聚苯胺（PANI）和氧化锰制备了三元纳米复合材料。由于亲水性的 GOQD 和 PANI，所得的 GPM 纳米复合材料很容易分散在水中，并且在 365 nm 光照射下对革兰氏阴性大肠杆菌( E. coli ) 和革兰氏阳性表皮葡萄球菌( S. epidermidis ) 表现出抗菌活性。值得注意的是，尽管两个样品具有相似的元素组成和平均 Mn 价态，但发现具有高 Mn ²⁺和 Mn ⁴⁺含量的纳米复合材料比具有主要 Mn ³⁺成分的纳米复合材料活性更高。杀菌活性很大程度上归因于光催化产生羟基自由基和光生空穴；已知两者都会对细菌细胞产生氧化应激。纳米复合材料对细胞表面的强亲和力可能会产生进一步的抗菌作用。这些结果表明，金属价态可能是基于金属氧化物纳米复合材料的高性能抗菌剂的设计和工程中的关键参数。

更新日期：2021-09-20

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