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Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography
Journal of Biomedical Optics ( IF 3.0 ) Pub Date : 2021-08-01 , DOI: 10.1117/1.jbo.26.8.086005
Giriraj K Sharma 1, 2 , Lily Y Chen 2 , Lidek Chou 3 , Christopher Badger 4 , Ellen Hong 2 , Swathi Rangarajan 3 , Theodore H Chang 3 , William B Armstrong 1 , Sunil P Verma 1 , Zhongping Chen 2, 5 , Ram Ramalingam 3 , Brian J-F Wong 1, 2, 5
Affiliation  

Significance: The human vocal fold (VF) oscillates in multiple vectors and consists of distinct layers with varying viscoelastic properties that contribute to the mucosal wave. Office-based and operative laryngeal endoscopy are limited to diagnostic evaluation of the VF epithelial surface only and are restricted to axial-plane characterization of the horizontal mucosal wave. As such, understanding of the biomechanics of human VF motion remains limited. Aim: Optical coherence tomography (OCT) is a micrometer-resolution, high-speed endoscopic imaging modality which acquires cross-sectional images of tissue. Our study aimed to leverage OCT technology and develop quantitative methods for analyzing the anatomy and kinematics of in vivo VF motion in the coronal plane. Approach: A custom handheld laryngeal stage was used to capture OCT images with 800 A-lines at 250 Hz. Automated image postprocessing and analytical methods were developed. Results: Novel kinematic analysis of in vivo, long-range OCT imaging of the vibrating VF in awake human subjects is reported. Cross-sectional, coronal-plane panoramic videos of the larynx during phonation are presented with three-dimensional videokymographic and space-time velocity analysis of VF motion. Conclusions: Long-range OCT with automated computational methods allows for cross-sectional dynamic laryngeal imaging and has the potential to broaden our understanding of human VF biomechanics and sound production.

中文翻译:

使用光学相干断层扫描在发声期间体内人声带的表面运动学和深度分辨分析

意义:人类声带 (VF) 在多个向量中振荡,并由具有不同粘弹性特性的不同层组成,这些层有助于黏膜波。门诊和手术喉内窥镜检查仅限于 VF 上皮表面的诊断评估,仅限于水平粘膜波的轴向平面表征。因此,对人类 VF 运动的生物力学的理解仍然有限。目的:光学相干断层扫描 (OCT) 是一种微米分辨率的高速内窥镜成像模式,可获取组织的横截面图像。我们的研究旨在利用 OCT 技术并开发定量方法来分析冠状平面中体内 VF 运动的解剖学和运动学。方法:使用定制的手持喉部平台以 250 Hz 的频率捕获具有 800 条 A 线的 OCT 图像。开发了自动图像后处理和分析方法。结果:报告了清醒人类受试者中振动 VF 的体内、远程 OCT 成像的新运动学分析。用 VF 运动的三维 videokymographic 和时空速度分析呈现发声期间喉部的横截面冠状面全景视频。结论:具有自动计算方法的远程 OCT 允许横截面动态喉成像,并有可能扩大我们对人类 VF 生物力学和声音产生的理解。报告了清醒人类受试者中振动 VF 的远程 OCT 成像。用 VF 运动的三维 videokymographic 和时空速度分析呈现发声期间喉部的横截面冠状面全景视频。结论:具有自动计算方法的远程 OCT 允许横截面动态喉成像,并有可能扩大我们对人类 VF 生物力学和声音产生的理解。报告了清醒人类受试者中振动 VF 的远程 OCT 成像。用 VF 运动的三维 videokymographic 和时空速度分析呈现发声期间喉部的横截面冠状面全景视频。结论:具有自动计算方法的远程 OCT 允许横截面动态喉成像,并有可能扩大我们对人类 VF 生物力学和声音产生的理解。
更新日期:2021-08-19
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