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A role for cerebral cortex in the suppression of innate defensive behaviour
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-08-17 , DOI: 10.1111/ejn.15426 Silvia Natale 1, 2 , Maria Esteban Masferrer 1 , Senthilkumar Deivasigamani 1 , Cornelius T Gross 1
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-08-17 , DOI: 10.1111/ejn.15426 Silvia Natale 1, 2 , Maria Esteban Masferrer 1 , Senthilkumar Deivasigamani 1 , Cornelius T Gross 1
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The cerebral cortex is widely accepted to be involved in the control of cognition and the processing of learned information. However, data suggest that it may also have a role in the regulation of innate responses because rodents, cats or primates with surgical removal of cortical regions show excessive aggression and rage elicited by threatening stimuli. Nevertheless, the imprecision and chronic nature of these lesions leave open the possibility that compensatory processes may underlie some of these phenotypes. In the present study we applied a precise, rapid and reversible inhibition approach to examine the contribution of the cerebral cortex to defensive behaviours elicited by a variety of innately aversive stimuli in laboratory mice. Pharmacological treatment of mice carrying the pharmacogenetic inhibitory receptor hM4D selectively in neocortex, archicortex and related dorsal telencephalon-derived structures resulted in the rapid inhibition of cerebral cortex neural activity. Cortical inhibition was associated with a selective increase in defensive behaviours elicited by an aggressive conspecific, a novel prey and a physically stressful stimulus. These findings are consistent with a role for cortex in the acute inhibition of innate defensive behaviours.
中文翻译：
大脑皮层在抑制先天防御行为中的作用
大脑皮层被广泛认为参与认知控制和学习信息的处理。然而，数据表明它也可能在先天反应的调节中起作用，因为通过手术切除皮质区域的啮齿动物、猫或灵长类动物表现出由威胁性刺激引起的过度攻击和愤怒。然而，这些病变的不精确性和慢性性质使代偿过程可能成为其中一些表型的基础。在本研究中，我们应用了一种精确、快速和可逆的抑制方法来检查大脑皮层对实验室小鼠各种先天厌恶刺激引起的防御行为的贡献。在新皮质、原皮质和相关的背侧端脑衍生结构中选择性携带药物遗传抑制受体 hM4D 的小鼠的药物治疗导致大脑皮质神经活动的快速抑制。皮质抑制与由侵略性同种、新猎物和身体压力刺激引起的防御行为的选择性增加有关。这些发现与皮层在先天防御行为的急性抑制中的作用一致。
更新日期：2021-09-21
中文翻译：
大脑皮层在抑制先天防御行为中的作用
大脑皮层被广泛认为参与认知控制和学习信息的处理。然而，数据表明它也可能在先天反应的调节中起作用，因为通过手术切除皮质区域的啮齿动物、猫或灵长类动物表现出由威胁性刺激引起的过度攻击和愤怒。然而，这些病变的不精确性和慢性性质使代偿过程可能成为其中一些表型的基础。在本研究中，我们应用了一种精确、快速和可逆的抑制方法来检查大脑皮层对实验室小鼠各种先天厌恶刺激引起的防御行为的贡献。在新皮质、原皮质和相关的背侧端脑衍生结构中选择性携带药物遗传抑制受体 hM4D 的小鼠的药物治疗导致大脑皮质神经活动的快速抑制。皮质抑制与由侵略性同种、新猎物和身体压力刺激引起的防御行为的选择性增加有关。这些发现与皮层在先天防御行为的急性抑制中的作用一致。
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