Nucleic Acid Integrated Technologies for Electrochemical Point-of-Care Diagnostics: A Comprehensive Review,Electroanalysis

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Nucleic Acid Integrated Technologies for Electrochemical Point-of-Care Diagnostics: A Comprehensive Review
Electroanalysis ( IF 2.7 ) Pub Date : 2021-08-18 , DOI: 10.1002/elan.202100309
Ozge Surucu ₁ , Elif Öztürk ₂ , Filiz Kuralay ₂

Affiliation

The need for routine and immediate healthcare monitoring has inspired “near-patient testing” or in other words “point-of-care testing (POCT)”. Therefore, POCT can be defined as laboratory tests that are performed at the patient's bedside or in the immediate vicinity of the incident. Among many POCTs, nucleic acid-based testing has attracted enormous attention for the diagnosis of important genetic, inherited and infectious diseases such as cancer and coronavirus. In this review, we outline the integration of nucleic acids into the remarkable electrochemical point-of-care diagnostics including microfluidic, paper and smartphone-based approaches, CRISPR/Cas and liquid biopsy related systems and DNA damage monitoring.

中文翻译：

用于电化学床旁诊断的核酸集成技术：综合综述

对常规和即时医疗保健监测的需求激发了“近病人检测”或换句话说“即时检测 (POCT)”的灵感。因此，POCT 可以定义为在患者床边或事件附近进行的实验室测试。在众多 POCT 中，基于核酸的检测在癌症和冠状病毒等重要遗传、遗传和传染病的诊断方面引起了极大的关注。在这篇综述中，我们概述了将核酸整合到卓越的电化学即时诊断中，包括基于微流体、纸张和智能手机的方法、CRISPR/Cas 和液体活检相关系统以及 DNA 损伤监测。

更新日期：2021-08-18

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