Background

Unlike other non-steroidal anti-inflammatory drugs, indomethacin has been shown to be highly effective in two forms of trigeminal autonomic cephalalgias, hemicrania continua and paroxysmal hemicrania and in some forms of idiopathic stabbing headaches. This specificity is unique in the headache field. Previous findings suggest the involvement of the trigeminal autonomic reflex to play an important role in the pathophysiology of these diseases.

Methods

22 healthy participants were enrolled in a double-blind, three-day within-subject design. The participants received indomethacin, ibuprofen or placebo in a randomized order. After an incubation period of 65 min the baseline lacrimation and the lacrimation during intranasal stimulation evoked by kinetic oscillation stimulation were assessed using Schirmer II lacrimation tests. The lacrimation difference in mm was calculated and compared in a repeated measures ANOVA.

Results

No significant differences were found between the three conditions.

Conclusion

In our study, neither indomethacin nor ibuprofen had an inhibitory effect on the trigeminal autonomic reflex. We suggest that blocking this reflex may not be the treatment mechanism of indomethacin.

中文翻译：

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消炎痛对三叉神经诱发的副交感神经输出没有影响

背景

与其他非甾体抗炎药不同，消炎痛已被证明对两种形式的三叉神经自主神经性头痛、持续性偏头痛和阵发性偏头痛以及某些形式的特发性刺痛非常有效。这种特异性在头痛领域是独一无二的。先前的研究结果表明，三叉神经自主反射在这些疾病的病理生理学中起重要作用。

方法

22 名健康参与者参加了一项为期三天的双盲受试者内设计。参与者以随机顺序接受消炎痛、布洛芬或安慰剂。在 65 分钟的潜伏期后，使用 Schirmer II 流泪测试评估基线流泪和由动力学振荡刺激引起的鼻内刺激期间的流泪。以毫米为单位计算流泪差异并在重复测量方差分析中进行比较。

结果

三个条件之间没有发现显着差异。

结论

在我们的研究中，消炎痛和布洛芬对三叉神经自主反射均无抑制作用。我们认为阻断这种反射可能不是消炎痛的治疗机制。