A Carbodiimide Cross-Linked Silk Fibroin/Sodium Alginate Composite Hydrogel with Tunable Properties for Sustained Drug Delivery,Macromolecular Materials and Engineering

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A Carbodiimide Cross-Linked Silk Fibroin/Sodium Alginate Composite Hydrogel with Tunable Properties for Sustained Drug Delivery
Macromolecular Materials and Engineering ( IF 4.2 ) Pub Date : 2021-08-18 , DOI: 10.1002/mame.202100470
Yiyu Wang _{1,

2} , Chunqing Niu ₂ , Jian Shi ₃ , Wenlong Yu ₂ , Chunhong Zhu ₄ , Qin Zhang ₅ , Mamoru Mizuno ₃

Affiliation

Carbodiimide cross-linked silk fibroin (SF)/sodium alginate (SA) composite hydrogels with superior stability and tunable properties are developed by varying preparation parameters. SF/SA blend ratio modulation allows to achieve composite hydrogel gelation times of 18–65 min, and rheological analysis shows that the speed of gel formation, the hydrogel network's density, and the hydrogels’ compressive properties are closely related to the blend ratio. The G′ of different hydrogels varies substantially from 28 to 413 Pa, and the hydrogel with higher SF content has a greater stiffness. The composite hydrogels present appropriate porosity of 76.63–85.09% and pore size of 316–603 µm. Hydrogel stability improves significantly after cross-linking, and substantial swelling occurs due to the hydrophilicity of SA. The 7/3 and 6/4 SF/SA hydrogels are more resistant to degradation in PBS, and cytotoxicity testing confirmed their biocompatibility. For release studies in vitro, two model compounds are used as drug models, tetracycline hydrochloride, and bovine serum albumin (BSA). Different ratios of SF/SA have a greater influence on the release of BSA. This study provides a practical preparation method for flexible SF/SA composite hydrogels, which can help design hydrogels with specific physicochemical properties for different applications, especially drug delivery.

中文翻译：

碳二亚胺交联丝蛋白/海藻酸钠复合水凝胶，具有可调节的持续给药特性

碳二亚胺交联丝素蛋白 (SF)/海藻酸钠 (SA) 复合水凝胶具有优异的稳定性和可调性能是通过不同的制备参数开发的。SF/SA 混合比例调制允许实现复合水凝胶凝胶时间为 18-65 分钟，流变学分析表明凝胶形成速度、水凝胶网络密度和水凝胶的压缩性能与混合比例密切相关。该摹不同水凝胶的 ' 从 28 Pa 到 413 Pa 变化很大，SF 含量较高的水凝胶具有更大的刚度。复合水凝胶的孔隙率为 76.63-85.09%，孔径为 316-603 µm。交联后水凝胶的稳定性显着提高，并且由于 SA 的亲水性而发生显着的溶胀。7/3 和 6/4 SF/SA 水凝胶更能抵抗 PBS 中的降解，细胞毒性测试证实了它们的生物相容性。对于体外释放研究，使用两种模型化合物作为药物模型，即盐酸四环素和牛血清白蛋白 (BSA)。不同比例的SF/SA对BSA的释放影响较大。该研究为柔性SF/SA复合水凝胶的制备提供了一种实用的方法，

更新日期：2021-08-18

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