Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus infection,Liver International

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Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus infection
Liver International ( IF 6.0 ) Pub Date : 2021-08-19 , DOI: 10.1111/liv.15041
Takako Inoue ₁ , Yui Funatsu ₂ , Masaya Ohnishi _{3,

4} , Masanori Isogawa ₄ , Keigo Kawashima ₄ , Masaru Tanaka ₂ , Kei Moriya ₅ , Hideto Kawaratani ₅ , Rie Momoda ₂ , Etsuko Iio ₆ , Hidewaki Nakagawa ₇ , Yutaka Suzuki ₈ , Kentaro Matsuura ₆ , Kei Fujiwara ₆ , Atsushi Nakajima ₉ , Hitoshi Yoshiji ₅ , Jiro Nakayama ₂ , Yasuhito Tanaka _{1,

4,

10}

Affiliation

Department of Clinical Laboratory Medicine, Nagoya City University Hospital, Nagoya, Japan.
Laboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan.
Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

We recently analysed and reported the features of the micro biome under hepatitis C virus (HCV) infection, but the effect of HCV infection on bile acid (BA) metabolism in the gut-liver axis remains poorly understood. The aim of this study was to clarify the characteristics of the gut-liver axis in HCV-infected patients.

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