Poly(ethylene terephthalate) (PET) is known for its various useful characteristics, including its applicability in cardiovascular applications, more precisely as synthetic bypass grafts for large diameter (≥ 6 mm) blood vessels. Although it is widely used, PET is not an optimal material as it is not interactive with endothelial cells, which is required for bypasses to form a complete endothelium. Therefore, in this study, poly(alkylene terephthalate)s (PATs) have been studied. They were synthesized via a single-step solution polycondensation reaction, which requires mild reaction conditions and avoids the use of a catalyst or additives like heat stabilizers. A homologous series was realized in which the alkyl chain length varied from 5 to 12 methylene groups (n = 5–12). Molar masses up to 28,000 g/mol were obtained, while various odd-even trends were observed with modulated differential scanning calorimetry (mDSC) and rapid heat-cool calorimetry (RHC) to access the thermal properties within the homologous series. The synthesized PATs have been subjected to in vitro cell viability assays using Human Umbilical Vein Endothelial Cells (HUVECs) and Human Dermal Microvascular Endothelial Cells (HDMECs). The results showed that HUVECs adhere and proliferate most pronounced onto PAT_(n=9) surfaces, which could be attributed to the surface roughness and morphology as determined by atomic force microscopy (AFM) (i.e. R_q = 204.7 nm). HDMECs were investigated in the context of small diameter vessels and showed superior adhesion and proliferation after seeding onto PAT_(n=6) substrates. These preliminary results already pave the way towards the use of PAT materials as substrates to support endothelial cell adhesion and growth. Indeed, as superior endothelial cell interactivity compared to PET was observed, time-consuming and costly surface modifications of PET grafts could be avoided by exploiting this novel material class.

聚对苯二甲酸乙二醇酯 (PET) 以其各种有用的特性而闻名，包括其在心血管应用中的适用性，更准确地说是作为用于大直径 (≥ 6 mm) 血管的合成旁路移植物。尽管它被广泛使用，但 PET 不是最佳材料，因为它不与内皮细胞相互作用，而内皮细胞是旁路形成完整内皮所必需的。因此，在本研究中，对聚对苯二甲酸亚烷基酯 (PAT) 进行了研究。它们是通过一步溶液缩聚反应合成的，该反应需要温和的反应条件并避免使用催化剂或热稳定剂等添加剂。实现了一个同源系列，其中烷基链长度从 5 到 12 个亚甲基（n = 5–12）。获得了高达 28,000 g/mol 的摩尔质量，同时使用调制差示扫描量热法 (mDSC) 和快速热冷量热法 (RHC) 观察到各种奇偶趋势，以获取同源系列内的热性能。使用人脐静脉内皮细胞 (HUVEC) 和人真皮微血管内皮细胞 (HDMEC) 对合成的 PAT 进行了体外细胞活力测定。结果表明，HUVECs 在 PAT _{( n = 9)}表面上的粘附和增殖最为明显，这可能归因于原子力显微镜 (AFM) 测定的表面粗糙度和形态（即 R _q = 204.7 纳米）。HDMECs 在小直径血管的背景下进行了研究，并在接种到 PAT _{( n = 6)}基质上后显示出优异的粘附和增殖。这些初步结果已经为使用 PAT 材料作为支持内皮细胞粘附和生长的基材铺平了道路。事实上，由于观察到与 PET 相比具有更好的内皮细胞相互作用，因此可以通过利用这种新型材料类别来避免对 PET 移植物进行耗时且昂贵的表面修饰。