Injectable hydrogels, of which the cover area and volume can be flexibly adjusted according to the shape and depth of the wound, are considered to be an ideal material for wound dressing. Konjac glucomannan (KGM) is a natural polysaccharide with immunomodulatory capability, while γ-polyglutamic acid (γ-PGA) is a single chain polyamino acid with moisturizing, water-retention and antibacterial properties. This work intended to combine the advantages of the two materials to prepare an injectable hydrogel (P-OK) by mixing the adipic acid dihydrazide (ADH) modified γ-PGA with oxidized KGM. The chemical structures, the physical and chemical properties, and the biological properties of the P-OK hydrogel were evaluated. The optimal conditions to form the P-OK hydrogel were fixed, and the cytotoxicity, qPCR, antibacterial and animal experiments were performed. Results showed that the P-OK hydrogel had a fast gelation time, good water-retention rate, little cytotoxicity, good immunomodulating and antibacterial capabilities, and could shorten the healing period in the rat full-thickness defect model, which makes it a potential candidate for wound repair dressing.

可根据伤口形状和深度灵活调节覆盖面积和体积的可注射水凝胶被认为是一种理想的伤口敷料材料。魔芋葡甘露聚糖（KGM）是一种具有免疫调节能力的天然多糖，而γ-聚谷氨酸（γ-PGA）是一种具有保湿、保水和抗菌性能的单链聚氨基酸。这项工作旨在通过将己二酸二酰肼 (ADH) 改性的 γ-PGA 与氧化的 KGM 混合，结合两种材料的优点来制备可注射水凝胶 (P-OK)。对P-OK水凝胶的化学结构、理化性质和生物学性质进行了评价。形成 P-OK 水凝胶的最佳条件是固定的，细胞毒性、qPCR、进行了抗菌和动物实验。结果表明，P-OK水凝胶凝胶时间快，保水率好，细胞毒性小，具有良好的免疫调节和抗菌能力，可以缩短大鼠全层缺损模型的愈合时间，使其成为潜在的候选者。用于伤口修复敷料。