3D-printed scaffolds have been developed as potential therapeutic strategies in bone tissue engineering. Mg/PCL biomaterials have been attracted much attention owing to biocompatibility, biodegradability as well as tunable mechanical properties. In this work, we developed 3D-printed customized Mg/PCL composite scaffolds with enhanced osteogenesis and biomineralization. Mg microparticles embedded in PCL-based scaffolds took a positive role in the improvement of biocompatibility, biomineralization, and biodegradable abilities. When incorporated with 3 wt% Mg, PCL-based scaffolds exhibited the optimal bone repairing ability in vitro and in vivo. The in vitro experiments indicated that 3 Mg/PCL scaffolds had improved mechanical properties, good biocompatibility, enhanced osteogenic and angiogenic activities. Besides, the in vivo studies demonstrated that Mg/PCL scaffolds promoted tissue ingrowth and new bone formation. In sum, these findings indicated that 3D-printed cell-free Mg/PCL scaffolds are promising strategies for bone healing application.

3D 打印支架已被开发为骨组织工程中的潜在治疗策略。Mg/PCL 生物材料由于其生物相容性、生物降解性以及可调节的机械性能而备受关注。在这项工作中，我们开发了 3D 打印的定制 Mg/PCL 复合支架，具有增强的成骨和生物矿化。嵌入基于 PCL 的支架中的镁微粒在提高生物相容性、生物矿化和生物降解能力方面发挥了积极作用。当与 3 wt% Mg 结合时，基于 PCL 的支架在体外和体内表现出最佳的骨修复能力。体外实验表明，3 Mg/PCL 支架具有改善的机械性能、良好的生物相容性、增强的成骨和血管生成活性。除了，体内研究表明，Mg/PCL 支架促进组织向内生长和新骨形成。总之，这些发现表明 3D 打印的无细胞 Mg/PCL 支架是用于骨愈合应用的有前途的策略。