Obesity is fast becoming a worldwide health concern and causes a chronic state of oxidative stress and low-grade inflammation, which could be major risk factors for a number of chronic diseases. We investigated the potential of the 61 probiotic candidates isolated from infant feces towards activity of lipid accumulation inhibition, and then we extended the study to evaluate their antidiabetic and antioxidant activity. Seven strains were finally selected based on their ability to inhibit lipid accumulation (>60%) and productivity yield (>1 × 10¹¹ colony forming units [CFU]/g): Lactobacillus acidophilus MG4558; Lactobacillus paracasei MG4592; Lactobacillus plantarum MG4553 and MG4555; and Lactobacillus rhamnosus MG4502, MG4511, and MG4505. Selected strains showed high α-glucosidase-inhibiting activity (> 50%), except for MG4511 (19.8%), and similar antioxidant activities were reflected by the results of DPPH (21.6–27.5%) and ABTS (40.9–44.9%) assays. With respect to their functional properties as probiotics, most of the strains were resistant to simulated gastric (pH 3 and 4) and intestinal (pH 7 and 8) fluids, and possessed various probiotic-related factors, including autoaggregation ability, antibiotic susceptibility, enzyme production, and biochemical profiles, and were non-hemolytic. We conclude that our strains may be good probiotic candidates for functional food ingredients to prevent metabolic disorders such as obesity and diabetes.

肥胖正迅速成为一个全球性的健康问题，并导致氧化应激和低度炎症的慢性状态，这可能是许多慢性疾病的主要危险因素。我们研究了从婴儿粪便中分离出的 61 种候选益生菌对脂质积累抑制活性的潜力，然后我们扩展了研究以评估它们的抗糖尿病和抗氧化活性。最终根据抑制脂质积累的能力 (>60%) 和生产力产量 (>1 × 10 ¹¹菌落形成单位 [CFU]/g)选择了 7 个菌株：嗜酸乳杆菌MG4558；副干酪乳杆菌MG4592；植物乳杆菌MG4553和MG4555；和鼠李糖乳杆菌MG4502、MG4511 和 MG4505。除 MG4511 (19.8%) 外，所选菌株显示出高 α-葡萄糖苷酶抑制活性 (> 50%)，DPPH (21.6-27.5%) 和 ABTS (40.9-44.9%) 测定结果反映了类似的抗氧化活性. 就其作为益生菌的功能特性而言，大多数菌株对模拟胃液（pH 3 和 4）和肠液（pH 7 和 8）具有抗性，并具有各种与益生菌相关的因素，包括自动聚集能力、抗生素敏感性、酶生产和生化特征，并且是非溶血性的。我们得出的结论是，我们的菌株可能是用于预防肥胖和糖尿病等代谢紊乱的功能性食品成分的良好益生菌候选物。