Abstract

The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA–protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific nucleotide sequences. Formation of such contacts with the double-stranded RNAs is hindered, so that the proteins recognize unique conformations of the RNA spatial structure and interact mainly with the RNA sugar-phosphate backbone.

中文翻译：

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蛋白质与单链和双链 RNA 相互作用的特征

摘要

该综述使用 RNA-蛋白质复合物结构的数据讨论了特定蛋白质与单链和双链 RNA 分子相互作用之间的差异。与单链 RNA 相互作用的蛋白质与 RNA 碱基形成接触，从而确保识别特定核苷酸序列。与双链 RNA 形成这种接触受到阻碍，因此蛋白质识别 RNA 空间结构的独特构象并主要与 RNA 糖-磷酸骨架相互作用。