Abstract

A-minor motifs are RNA tertiary structure motifs that generally involve a canonical base pair and an adenine base forming hydrogen bonds with the minor groove of the base pair. Such motifs are among the most common tertiary interactions in known RNA structures, comparable in number with the non-canonical base pairs. They are often found in functionally important regions of non-coding RNAs and, in particular, play a central role in protein synthesis. Here, we review local variations of the A-minor geometry and discuss difficulties associated with their annotation, as well as various structural contexts and common A-minor co-motifs, and diverse functions of A-minors in various processes in a living cell.

中文翻译：

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A-小调基序的特征和功能，RNA 结构中最常见的基序

摘要

A-小基序是RNA三级结构基序，通常涉及一个规范碱基对和一个腺嘌呤碱基，与碱基对的小沟形成氢键。此类基序是已知 RNA 结构中最常见的三级相互作用之一，其数量与非规范碱基对相当。它们通常存在于非​​编码 RNA 的功能重要区域，尤其是在蛋白质合成中发挥核心作用。在这里，我们回顾了 A 小调几何形状的局部变化，并讨论了与它们的注释相关的困难，以及各种结构背景和常见的 A 小调共同基元，以及 A 小调在活细胞的各种过程中的不同功能。