Abstract

A new lanthanum complex with 2,5-bis((3-carboxylphenyl)amino)terephthalic acid is synthesized by a solvent thermal reaction. The La(III) complex monomer forms a chain by hydrogen bonding. The interaction mode of the complex with DNA is studied by fluorescence spectroscopy, and the result match the molecular docking test, the complex binds to the DNA by insertion, the fluorescence quenching constant is 0.1257. The particle size of the crystal powder is about 500 nm, which can be observed by SEM. The complex demonstrates a good anticancer activity.

中文翻译：

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由长柔性配体构建的新型 La(III) 复合物：晶体结构、DNA 结合和分子对接研究

摘要

通过溶剂热反应合成了一种新的镧与2,5-双((3-羧基苯基)氨基)对苯二甲酸的配合物。La(III) 络合物单体通过氢键形成链。用荧光光谱研究了配合物与DNA的相互作用方式，结果与分子对接试验相符，配合物通过插入与DNA结合，荧光猝灭常数为0.1257。晶体粉末的粒径约为500 nm，可通过SEM观察。该复合物显示出良好的抗癌活性。