Introduction: Weight loss and increased physical activity interventions are commonly recommended for individuals with type 2 diabetes (T2D) and overweight or obesity. We examined the impact of randomization to an intensive lifestyle intervention (ILI) on trajectories of cognitive function over 10 years in a cohort of participants in a randomized clinical trial who had T2D and overweight/obesity at baseline. Methods: Participants aged 45–76 years were enrolled in 2001–2004 and were randomized to the ILI or a diabetes support and education (DSE) condition. Cognitive function was assessed in 3,938 participants at up to 4 time points 8–18 years after randomization. General linear mixed effects models examined cognitive trajectories over time. Subgroup analyses focused on sex, individuals with baseline body mass index #x3e;30, those carrying the APOE ε4 allele, and those with a baseline history of cardiovascular disease (CVD). Results: Overall, there were no differences in the rate of cognitive decline by intervention arm. Subgroup analyses showed that participants who had a baseline history of CVD and were randomized to the ILI arm of the study performed significantly worse on the Stroop Color Word Test than those in the DSE arm. Discussion/Conclusions: The ILI did not result in preserved cognitive function or slower rates of cognitive decline in this cohort of individuals who had T2D and were overweight or obese at baseline.
Dement Geriatr Cogn Disord

中文翻译：

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10 年多领域生活方式干预对超重/肥胖和 2 型糖尿病患者认知轨迹的影响


简介：通常建议 2 型糖尿病 (T2D) 和超重或肥胖患者采取减肥和增加体力活动干预措施。我们在一项随机临床试验的一组参与者中研究了强化生活方式干预 (ILI) 的随机化对 10 年来认知功能轨迹的影响，这些参与者在基线时患有 T2D 和超重/肥胖。方法： 2001 年至 2004 年期间，年龄为 45-76 岁的参与者被随机分配到 ILI 或糖尿病支持和教育 (DSE) 条件组。在随机分组后 8-18 年的最多 4 个时间点对 3,938 名参与者的认知功能进行了评估。一般线性混合效应模型检查了一段时间内的认知轨迹。亚组分析重点关注性别、基线体重指数 #x3e;30 的个体、携带APOE ε4 等位基因的个体以及具有基线心血管疾病 (CVD) 病史的个体。结果：总体而言，干预组的认知能力下降率没有差异。亚组分析显示，有 CVD 基线病史并被随机分配到研究 ILI 组的参与者在 Stroop 色词测试中的表现明显比 DSE 组的参与者差。讨论/结论：对于基线时超重或肥胖的 T2D 患者群体，ILI 并未导致认知功能得以保留或认知能力下降速度减慢。

老年痴呆症认知障碍