Purpose of Review

Heart failure remains a major public health concern with high burden of morbidity and mortality despite advances in pharmacotherapy, device therapy, and surgical and percutaneous techniques. Cardiac regeneration may have a role to play in these patients with a huge unmet need for these therapies in patients with chronic ischemic heart disease, post-infarct heart failure, dilated cardiomyopathy, and heart failure with preserved ejection fraction.

Recent Findings

In this review, we focus on the pre-clinical and translational basis for different modes of cardiac regenerative medicine and then critically appraise the clinical evidence amassed from pivotal clinical trials focused on cardiac regeneration for ischemic and non-ischemic cardiomyopathies.

Summary

Cardiac regenerative medicine is rapidly evolving with novel approaches involving cell-based, cell-free, tissue engineering, and hybrid therapies to achieve myocardial regeneration and repair. Further studies are warranted with a robust comparison arm with optimal contemporary medical therapy to translate regenerative therapies to a clinical reality.

中文翻译：

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心力衰竭再生治疗的现状如何？

审查目的

尽管药物治疗、器械治疗以及外科和经皮技术取得了进步，但心力衰竭仍然是一个主要的公共卫生问题，具有很高的发病率和死亡率。心脏再生可能在这些患者中发挥作用，慢性缺血性心脏病、梗死后心力衰竭、扩张型心肌病和射血分数保留的心力衰竭患者对这些治疗的巨大需求未得到满足。

最近的发现

在这篇综述中，我们关注不同心脏再生医学模式的临床前和转化基础，然后批判性地评价从关注缺血性和非缺血性心肌病心脏再生的关键临床试验中积累的临床证据。

概括

心脏再生医学正在迅速发展，新方法包括基于细胞的、无细胞的、组织工程和混合疗法，以实现心肌再生和修复。进一步的研究需要一个强大的比较臂和最佳的当代医学疗法，以将再生疗法转化为临床现实。