Colloid and Polymer Science ( IF 2.2 ) Pub Date : 2021-08-17 , DOI: 10.1007/s00396-021-04858-x Chenghuan Hua 1 , Wenjie Yu 1 , Mingyue Yang 1 , Qun Cai 1 , Tian Gao 1 , Silong Zhang 1 , Huan Xu 1 , Huan He 1 , Na Peng 1 , Yi Liu 1, 2
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New nanocomplexes containing curcumin-loaded casein micelles and surface-coated pectin via electrostatic interaction were fabricated. Curcumin-loaded nanocomplexes prepared at pH 4 showed the most excellent performance than that at pH 3 and pH 2, which had an average size of 266.4 nm (polydispersity index = 0.193) and loading capacity of 93%. The morphology of nanocomplexes exhibited as monodisperse spherical nanoparticles observed by SEM and TEM. The experiment of anti-oxidant activity demonstrated that nanocomplexes tremendously kept the bioactivity of curcumin. Moreover, in vitro release behaviors of curcumin from casein-pectin nanocomplexes indicated that the surface coating layer of pectin obviously delayed the release of curcumin in simulated gastric fluid, and the controlled release ability in simulated intestinal fluid was greatly enhanced. The casein-pectin nanocomplexes exhibited as a promising oral delivery vehicle of bioactive ingredients in food and pharmacy.
Graphical abstract
中文翻译：
酪蛋白-果胶纳米复合物作为一种潜在的口服给药系统，可提高姜黄素的稳定性和生物活性
通过静电相互作用制备了含有姜黄素酪蛋白胶束和表面包覆果胶的新型纳米复合物。在 pH 4 下制备的姜黄素纳米复合物比在 pH 3 和 pH 2 下制备的纳米复合物表现出最优异的性能，其平均粒径为 266.4 nm（多分散指数 = 0.193），负载量为 93%。通过SEM和TEM观察到纳米复合物的形态表现为单分散球形纳米粒子。抗氧化活性实验表明，纳米复合物极大地保持了姜黄素的生物活性。此外，酪蛋白-果胶纳米复合物中姜黄素的体外释放行为表明，果胶的表面包衣层明显延迟了姜黄素在模拟胃液中的释放，在模拟肠液中的控释能力大大增强。
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