Colloid and Polymer Science ( IF 2.2 ) Pub Date : 2021-08-14 , DOI: 10.1007/s00396-021-04853-2 Nikolai P. Iakimov 1 , Elizabeth A. Dets 1 , Sergei S. Abramchuk 1, 2, 3 , Irina D. Grozdova 1 , Nikolay S. Melik-Nubarov 1 , Maxim A. Zotkin 4 , Alexander M. Arutyunian 5
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Here, we report on the evaluation of critical packing parameters, PC, of l-tyrosine and ethylene glycol (PEG) amphiphilic block copolymers. The copolymers were synthesized via l-tyrosine-N-carboxyanhydride ring-opening polymerization using different amino-terminated PEGs as macroinitiators. The size and shape of their associates formed in water were investigated by transmission electron microscopy and dynamic and static light scatterings. The copolymers containing 20–30 wt. % of Tyr formed rod-like micelles. The copolymers with 30–50 wt. % of Tyr formed spherical vesicles, while those with 50–80 wt. % Tyr formed irregularly shaped polymeric nanoparticles. PC of the copolymers was estimated as the ratio of the van der Waals volume of the hydrophobic block (V) to its length (L) and the cross-sectional area of the polar block (SH). The values of SH for each copolymer were calculated according to the equation obtained from the correlation analysis of the published data. The hydrophobic block length L was calculated in three ways, i.e., assuming that polytyrosine adopts (1) stretched, (2) amyloid hairpin, or (3) Gaussian coil conformation. In the latter case, the best match of the calculated PC values with the morphology of the copolymer assemblies was observed.
Graphical abstract
中文翻译：
聚酪氨酸-PEG两亲共聚物系列中关键堆积参数的评价
在这里，我们临界填充参数的评价，P报告Ç，的升-酪氨酸和乙二醇（PEG）的两亲性嵌段共聚物。共聚物是通过l-酪氨酸-N-羧酐开环聚合反应合成的，使用不同的氨基封端 PEG 作为大分子引发剂。通过透射电子显微镜和动态和静态光散射研究了它们在水中形成的缔合物的大小和形状。含有 20-30 重量份的共聚物。％的 Tyr 形成棒状胶束。具有 30-50 重量的共聚物。％的 Tyr 形成球形囊泡，而那些具有 50-80 wt. % Tyr 形成不规则形状的聚合物纳米颗粒。P ç共聚物的体积估计为疏水性嵌段的范德华体积 (V) 与其长度 (L) 和极性嵌段的横截面积 (S H )的比率。每种共聚物的 S H值是根据从公开数据的相关性分析中获得的方程计算的。疏水性嵌段长度L的计算方法有3种，即假设聚酪氨酸采用(1)拉伸、(2)淀粉样蛋白发夹、或(3)高斯螺旋构象。在后一种情况下，观察到计算的 P C值与共聚物组件的形态的最佳匹配。
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