The drug loading efficiency of magnetite nanoparticles (MNPs) can be enhanced by coating with polyethylene glycol (PEG) which is a biocompatible polymer. The PEG-coated MNPs could be the potential candidates for carrying the drug molecules to the targeted sites. In this study, size-controlled MNPs were synthesized and functionalized with PEG of molecular weights 700, 2000 and 5000. The MNPs and PEGylated MNPs (PMNPs) samples were characterized through X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM) and surface area and pore size measurements by Brunauer, Emmett and Teller (BET) and Barrett–Joyner–Halenda (BJH) methods. The diffraction data showed that MNPs are purely crystalline with face cubic crystal structure, whereas the spherical shape of the particles was confirmed by TEM. The TGA supports thermal stability of nanoparticles which was markedly enhanced by coating with PEG. The BJH data (hysteresis loops) showed that MNPs were mesoporous in nature. After characterization, the PEGylated MNPs were loaded with gallic acid (GA). The spectroscopic evidences regarding the successful PEGylation and loading of GA onto PMNPswere acquired from FTIR spectroscopy. The in vitro sustained drug release efficacy of PMNPs was evaluated via UV–visible spectroscopy. Among all the synthesized samples, P₇₅₀MNPs-10 showed the highest % drug release i.e., 98% into phosphate buffer saline (PBS) solution of pH 4.4 and 90% in PBS of pH 7.4. The highest % drug release at pH 10 may be attributed to smaller particle size with high surface area. The highest % drug release can also be associated with the weak interactions between P₇₅₀MNPs-10 and GA through hydrogen bonding.

磁铁矿纳米颗粒 (MNP) 的载药效率可以通过涂覆聚乙二醇 (PEG) 来提高，PEG 是一种生物相容性聚合物。PEG 包被的 MNPs 可能是将药物分子运送到目标位点的潜在候选者。在这项研究中，尺寸控制的 MNP 被合成并用分子量为 700、2000 和 5000 的 PEG 官能化。 MNP 和聚乙二醇化 MNP (PMNP) 样品通过 X 射线衍射 (XRD)、热重分析 (TGA)、傅立叶变换红外 (FTIR) 光谱、透射电子显微镜 (TEM) 以及通过 Brunauer、Emmett 和 Teller (BET) 和 Barrett-Joyner-Halenda (BJH) 方法测量的表面积和孔径。衍射数据表明，MNPs 是纯晶体，具有面立方晶体结构，而颗粒的球形则通过 TEM 确认。TGA 支持纳米粒子的热稳定性，这通过用 PEG 涂层显着增强。BJH 数据（滞后回线）表明 MNP 本质上是中孔的。表征后，聚乙二醇化的 MNP 加载没食子酸 (GA)。从 FTIR 光谱获得了关于成功聚乙二醇化和将 GA 加载到 PMNP 上的光谱证据。PMNPs 的体外持续药物释放功效通过紫外-可见光谱法进行评估。在所有合成样品中，P 聚乙二醇化的 MNP 负载了没食子酸 (GA)。从 FTIR 光谱获得了关于成功聚乙二醇化和将 GA 加载到 PMNP 上的光谱证据。PMNPs 的体外持续药物释放功效通过紫外-可见光谱法进行评估。在所有合成样品中，P 聚乙二醇化的 MNP 负载了没食子酸 (GA)。从 FTIR 光谱获得了关于成功聚乙二醇化和将 GA 加载到 PMNP 上的光谱证据。PMNPs 的体外持续药物释放功效通过紫外-可见光谱法进行评估。在所有合成样品中，P_{750 个}MNPs-10 显示出最高的药物释放百分比，即，在 pH 4.4 的磷酸盐缓冲盐水 (PBS) 溶液中为 98%，在 pH 7.4 的 PBS 中为 90%。pH 10 时最高的药物释放百分比可能归因于较小的粒径和较高的表面积。最高的药物释放百分比也可能与 P ₇₅₀ MNPs-10 和 GA 之间通过氢键的弱相互作用有关。