Curcumin is a natural polyphenol isolated from the rhizome of Curcuma longa with recognised therapeutic potential, namely as an anti-inflammatory, antioxidant, anticancer, and antidiabetic agent. Despite its potential biological properties, the low bioavailability of curcumin hinders its systemic effects. Recently, it was reported that the combination of curcumin with piperine increases their biological potential (e.g. antioxidant activity), by enhancing curcumin’s bioavailability. However, it is not known whether the two compounds have a direct synergic effect. In this study, we evaluated and compared the scavenging activity of physiological relevant reactive species by commercial curcumin extract, commercial piperine extract and their combination, using in vitro non-cellular and cellular systems. The obtained results revealed that the commercial curcumin extract scavenges hypochlorous acid and nitric oxide, while no scavenging effect was found against superoxide anion radical and hydrogen peroxide. The commercial curcumin extract also proved to be an effective inhibitor of neutrophils’ oxidative burst. Commercial piperine extract per se did not display any activity. Nevertheless, the obtained results for the combination of commercial curcumin extract with commercial piperine extract (1%) suggest that the commercial piperine extract potentiates the effects exerted by the commercial curcumin extract.

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使用体外非细胞和细胞模型，姜黄素、胡椒碱及其组合对生理相关活性促氧化物质的清除作用

姜黄素是从姜黄根茎中分离出来的一种天然多酚，具有公认的治疗潜力，即作为抗炎、抗氧化、抗癌和抗糖尿病药物。尽管具有潜在的生物学特性，姜黄素的低生物利用度阻碍了其全身作用。最近，据报道姜黄素与胡椒碱的组合增加了它们的生物潜力（例如。抗氧化活性），通过提高姜黄素的生物利用度。然而，尚不清楚这两种化合物是否具有直接的协同作用。在这项研究中，我们使用体外非细胞和细胞系统评估和比较了商业姜黄素提取物、商业胡椒碱提取物及其组合对生理相关活性物质的清除活性。所得结果表明，市售姜黄素提取物清除次氯酸和一氧化氮，而未发现对超氧阴离子自由基和过氧化氢的清除作用。商业姜黄素提取物也被证明是中性粒细胞氧化爆发的有效抑制剂。商业胡椒碱提取物本身没有显示任何活性。尽管如此，

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