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Hierarchical assemblies of polypeptoids for rational design of advanced functional nanomaterials
Biopolymers ( IF 3.2 ) Pub Date : 2021-08-18 , DOI: 10.1002/bip.23469
Mingfei Zhao 1
Affiliation  

Polypeptoids (poly-N-substituent glycines) are a class of highly tailorable peptidomimetic polymers. Polypeptoids have identical backbones as polypeptides (poly-C-substituent glycines), but sidechains of polypeptoids are appended to backbone nitrogen rather than α-carbon of polypeptides. As a result, peptoid backbone lacks of chirality and hydrogen bond donors. This unique structure gives polypeptoids a combined merit of both high stability as synthetic polymers and biocompatibility as biopolymers. In addition, peptoid sequences can be engineered precisely to assemble specific crystalline patterns such as spheres, fibers, ribbons, tubes, and sheets, which shows promising potentials of polypeptoids for different applications such as antimicrobials, catalysts, drug delivery, and templating inorganic materials. In this review, we summarize recent investigations into hierarchical self-assembly pathways and molecular structures of peptoid crystals that are of interest as templates for fabricating functional materials for potential biomedical, biochemical, and bioengineering applications. This review provides a summary of recent experimental and computational studies of polypeptoid assembly in solution and solid-liquid interfaces, current achievements in the field, and discusses future challenges and opportunities for the rational design of self-assembled polypeptoid nanomaterials.

中文翻译:

用于合理设计先进功能纳米材料的多肽的分层组装

多肽(聚-N-取代基甘氨酸)是一类高度可定制的拟肽聚合物。多肽与多肽(聚-C-取代基甘氨酸)具有相同的骨架,但多肽的侧链附加到骨架氮而不是多肽的α-碳。因此,拟肽骨架缺乏手性和氢键供体。这种独特的结构赋予多肽类化合物作为合成聚合物的高稳定性和作为生物聚合物的生物相容性的综合优点。此外,peptoid 序列可以精确地设计以组装特定的晶体模式,如球体、纤维、带、管和片材,这显示了 polypeptoid 在抗菌剂、催化剂、药物输送和模板无机材料等不同应用中的潜力。在本次审查中,我们总结了最近对 peptoid 晶体的分层自组装途径和分子结构的研究,这些研究可作为制造用于潜在生物医学、生化和生物工程应用的功能材料的模板。本综述总结了溶液和固液界面中多肽组装的最新实验和计算研究、该领域的当前成就,并讨论了自组装多肽纳米材料合理设计的未来挑战和机遇。
更新日期:2021-09-24
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