Data about the coronavirus disease 2019 (COVID-19) pandemic’s collateral damage on ischemic stroke (IS) care during the second epidemic wave in Central Europe are limited. We sought to evaluate the impact of the COVID-19 outbreak on Hungarian IS care during the two epidemic waves. This retrospective observational study was based on a nationwide reimbursement database that encompasses all IS admissions and all reperfusion interventions, i.e., intravenous thrombolysis (IVT) and endovascular therapy (EVT) from 2 January 2017 to 31 December 2020 in Hungary. COVID-19 pandemic’s effect on the number of IS admissions and reperfusion interventions were analyzed using different statistics: means, medians, trends, relative rates, and linear relationships. The mean and median values of IS admissions and reperfusion interventions decreased only in some measure during the COVID-periods. However, trend analysis demonstrated a significant decline from the trends. The decline’s dynamic and amplitude have differed for each variable. In contrast to IVT, the number of IS admissions and EVTs negatively correlated with the epidemic waves’ amplitude. Besides, the decrease in the number of IS admissions was more pronounced than the decrease in the number of reperfusion interventions. Our study demonstrated a significant disruption in IS care during the COVID-19 epidemic in Hungary, in which multiple different factors might play a role. The disproportionate reduction of IS admission numbers could partially be explained by the effect of health emergency operative measures and changes in patients’ social behavior. Further studies are needed to evaluate the causes of our observations.

在中欧第二波流行期间，有关 2019 年冠状病毒病 (COVID-19) 大流行对缺血性中风 (IS) 护理的附带损害的数据有限。我们试图评估在两次流行浪潮中 COVID-19 爆发对匈牙利 IS 护理的影响。这项回顾性观察性研究基于一个全国性的报销数据库，该数据库包括 2017 年 1 月 2 日至 2020 年 12 月 31 日在匈牙利的所有 IS 入院和所有再灌注干预，即静脉溶栓 (IVT) 和血管内治疗 (EVT)。使用不同的统计数据分析了 COVID-19 大流行对 IS 入院和再灌注干预次数的影响：平均值、中位数、趋势、相对比率和线性关系。在 COVID 期间，IS 入院和再灌注干预的平均值和中值仅在一定程度上有所下降。然而，趋势分析表明趋势显着下降。每个变量的下降动态和幅度都不同。与 IVT 相比，IS 入院和 EVT 的数量与流行波的幅度呈负相关。此外，IS入院次数的减少比再灌注干预次数的减少更为明显。我们的研究表明，在匈牙利 COVID-19 流行期间，IS 护理出现了重大中断，其中多种不同的因素可能发挥作用。IS入院人数的不成比例减少可以部分解释为卫生紧急手术措施的影响和患者社会行为的变化。