Metabolic diseases including type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS) are alarming health burdens around the world, while therapies for these diseases are far from satisfying as their etiologies are not completely clear yet. T2DM, NAFLD, and MetS are all complex and multifactorial metabolic disorders based on the interactions between genetics and environment. Omics studies such as genetics, transcriptomics, epigenetics, proteomics, and metabolomics are all promising approaches in accurately characterizing these diseases. And the most effective treatments for individuals can be achieved via omics pathways, which is the theme of precision medicine. In this review, we summarized the multi-omics studies of T2DM, NAFLD, and MetS in recent years, provided a theoretical basis for their pathogenesis and the effective prevention and treatment, and highlighted the biomarkers and future strategies for precision medicine.

中文翻译：

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多组学分析：代谢疾病精准医学之路


包括2型糖尿病（T2DM）、非酒精性脂肪性肝病（NAFLD）和代谢综合征（MetS）在内的代谢性疾病给全世界带来了令人担忧的健康负担，而这些疾病的治疗方法却远不能令人满意，因为它们的病因尚不完全清楚。还清楚。 T2DM、NAFLD 和 MetS 都是基于遗传和环境之间相互作用的复杂且多因素的代谢性疾病。遗传学、转录组学、表观遗传学、蛋白质组学和代谢组学等组学研究都是准确表征这些疾病的有前途的方法。对个体最有效的治疗可以通过组学途径实现，这就是精准医学的主题。本文综述了近年来T2DM、NAFLD和MetS的多组学研究，为其发病机制和有效预防和治疗提供理论依据，重点介绍了精准医疗的生物标志物和未来策略。