Objectives: 

Linked-color imaging (LCI) is a new image-enhancement option that emphasizes mucosal surface contrast, facilitating the differentiation between colorectal lesions and normal mucosa. This study aimed to evaluate the potential of LCI to increase the detection of colorectal adenomas in screening colonoscopies.

Methods: 

A prospective randomized study was conducted using white-light imaging (WLI), blue-laser imaging (BLI)-bright and LCI. The outcome measures were adenoma detection rate (ADR), mean number of adenomas per patient, and withdrawal time. Lesion characteristics such as size, morphology, location, and histology were also evaluated.

Results: 

A total of 205 patients were randomized, and 251 adenomas were detected. The overall ADR was 62%. The ADR was 52.9% for WLI, 62.1% for BLI-bright, and 71% for LCI, and was significantly higher in the LCI group than in the WLI group (P=0.04). No significant difference was observed between LCI and BLI-bright (P=0.28) or BLI-bright and WLI (P=0.30). The mean number of adenomas per patient was 1.01, 1.03, and 1.62 for WLI, BLI-bright, and LCI, respectively, with a significant difference (P=0.02). Withdrawal time did not differ among the groups. A total of 71 adenomas were detected by WLI, 68 by BLI-bright, and 112 by LCI. There was no difference in the size and morphology of the adenomas detected, nor in the diagnosis of sessile serrated adenomas/polyps.

Conclusion: 

LCI significantly increased the detection of adenomas in screening colonoscopies.

中文翻译：

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连色成像对结肠镜筛查中腺瘤检测的影响

目标： 

连色成像 (LCI) 是一种新的图像增强选项，强调粘膜表面对比度，有助于区分结直肠病变和正常粘膜。本研究旨在评估 LCI 在结肠镜检查中提高结直肠腺瘤检出率的潜力。

方法： 

使用白光成像 (WLI)、蓝色激光成像 (BLI)-bright 和 LCI 进行了一项前瞻性随机研究。结果指标是腺瘤检出率（ADR）、每位患者的平均腺瘤数和停药时间。还评估了病变特征，例如大小、形态、位置和组织学。

结果： 

共有 205 名患者被随机分组​​，检测出251 例腺瘤。总体 ADR 为 62%。WLI 组的 ADR 为 52.9%，BLI-bright 组为 62.1%，LCI 组为 71%，LCI 组的 ADR 显着高于 WLI 组（P =0.04）。LCI 和 BLI-bright ( P = 0.28) 或 BLI-bright 和 WLI ( P = 0.30)之间没有观察到显着差异。WLI、BLI-bright 和 LCI 患者平均腺瘤数分别为 1.01、1.03 和 1.62，差异显着（P =0.02）。各组之间的停药时间没有差异。WLI共检出71 例腺瘤，BLI-bright 检出 68 例，LCI 检出 112 例。检测到的腺瘤的大小和形态没有差异，无蒂锯齿状腺瘤/息肉的诊断也没有差异。

结论： 

LCI 显着增加了筛查结肠镜检查中腺瘤的检出率。