The advent of human gene editing has stimulated international interest in how best to govern this research. However, research on stakeholder views has neglected scientists themselves. We surveyed 212 scientists who use gene editing in their work. Questions captured views on oversight and use of somatic and germline human gene editing for treatment, prevention, and enhancement. More respondents were supportive of somatic than germline editing, and more supported gene editing for treatment compared to prevention. Few supported its use for enhancement. When presented with specific conditions, levels of support for somatic editing differed by type of condition. Almost all respondents said scientists and national government representatives should be involved in oversight, but only 28% said scientists are best positioned to oversee gene-editing research. These results can inform the development of sound approaches to research governance, demonstrating the importance of identifying specific gene-editing uses when considering oversight.

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专家组的观点：科学家对人类基因编辑研究的用途和治理的看法


人类基因编辑的出现激发了国际社会对如何最好地管理这项研究的兴趣。然而，对利益相关者观点的研究却忽视了科学家本身。我们调查了 212 名在工作中使用基因编辑的科学家。问题反映了对监督和使用体细胞和种系人类基因编辑进行治疗、预防和增强的看法。更多的受访者支持体细胞编辑而不是种系编辑，更多的受访者支持基因编辑用于治疗而不是预防。很少有人支持将其用于增强。当遇到特定条件时，对体细胞编辑的支持水平因条件类型而异。几乎所有受访者都表示科学家和国家政府代表应该参与监督，但只有 28% 的受访者表示科学家最适合监督基因编辑研究。这些结果可以为制定合理的研究治理方法提供信息，证明在考虑监督时确定特定基因编辑用途的重要性。