Role of IL-6 in dendritic cell functions,Journal of Leukocyte Biology

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Role of IL-6 in dendritic cell functions
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2021-08-18 , DOI: 10.1002/jlb.3mr0621-616rr
Yu-Dong Xu ₁ , Mi Cheng ₁ , Pan-Pan Shang ₁ , Yong-Qing Yang ₁

Affiliation

Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly involved in cellular and humoral immune responses by presenting antigens to initiate T cell reactions, cytokine and chemokine secretion, T cell differentiation and expansion, B cell activation and regulation, and the mediation of immune tolerance. The functions of DCs depend on their activation status, which is defined by the stages of maturation, phenotype differentiation, and migration ability, among other factors. IL-6 is a soluble mediator mainly produced by a variety of immune cells, including DCs, that exerts pleiotropic effects on immune and inflammatory responses through interaction with specific receptors expressed on the surface of target cells. Here, we review the role of IL-6, when generated in an inflammatory context or as derived from DCs, in modulating the biologic function and activation status of DCs and emphasize the importance of searching for novel strategies to target the IL-6/IL-6 signaling pathway as a means to diminish the inflammatory activity of DCs in immune response or to prime the immunogenic activity of DCs in immunosuppressive conditions.

中文翻译：

IL-6 在树突细胞功能中的作用

树突状细胞 (DC) 是有效的抗原呈递细胞，可作为先天免疫系统和适应性免疫系统之间的纽带。这些细胞通过呈递抗原以启动 T 细胞反应、细胞因子和趋化因子分泌、T 细胞分化和扩增、B 细胞活化和调节以及免疫耐受的介导，广泛参与细胞和体液免疫反应。DC 的功能取决于它们的激活状态，激活状态由成熟阶段、表型分化和迁移能力等因素决定。IL-6是一种可溶性介质，主要由包括DC在内的多种免疫细胞产生，通过与靶细胞表面表达的特定受体相互作用，对免疫和炎症反应发挥多效作用。在这里，我们回顾了 IL-6 的作用，

更新日期：2021-08-18

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