Depression is associated with suboptimal HIV care outcomes. Little is known about the extent to which the prevalence of depressive symptoms varies across the HIV care continuum. Also, the relationship among gender, HIV disclosure, HIV care stage, and depressive symptoms in PLWH remains poorly understood. We analyzed cross-sectional data from 12,507 PLWH at enrollment in International epidemiology Databases to Evaluate AIDS (IeDEA) Cameroon between 2016 and 2020. Recent depressive symptoms were assessed using the Patient Health Questionnaire-2 (PHQ-2). A score of three or greater on the PHQ-2 was considered indicative of likely major depressive disorder. We estimated the prevalence of depressive symptoms across three stages of HIV care: those not yet on antiretroviral therapy (ART), recent ART initiators (ART initiation ≤ 30 days prior), and ART users (ART initiation > 30 days prior). Adjusted prevalence differences (aPD) of depressive symptoms were estimated comparing recent ART initiators and ART users. Disclosure and gender were examined as effect measure modifiers of the relationship between HIV care stage and depressive symptoms. The prevalence of depressive symptoms was 11.9%, 22.0%, and 8.7% among PLWH not yet on ART, recent ART initiators, and ART users, respectively. ART users had significantly lower prevalence of depressive symptoms compared to recent ART initiators (aPD - 0.09 [95% CI - 0.11, - 0.08]). Neither gender nor HIV disclosure modified the effect measure of the relationship between HIV care stage and depressive symptoms. Depressive symptoms were commonly reported among this group of PLWH and were associated with recent ART initiation. Integration of screening and treatment of depression into HIV care should be prioritized and may be particularly relevant for PLWH initiating ART.

中文翻译：

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喀麦隆艾滋病毒感染者的抑郁症状、性别、披露和艾滋病毒护理阶段。


抑郁症与艾滋病毒护理结果不佳有关。人们对艾滋病毒护理过程中抑郁症状患病率的变化程度知之甚少。此外，艾滋病病毒感染者的性别、艾滋病毒披露、艾滋病毒护理阶段和抑郁症状之间的关系仍然知之甚少。我们分析了 2016 年至 2020 年间喀麦隆国际艾滋病评估流行病学数据库 (IeDEA) 登记的 12,507 名感染者的横断面数据。使用患者健康问卷 2 (PHQ-2) 评估近期抑郁症状。 PHQ-2 得分为 3 分或更高被认为表明可能患有重度抑郁症。我们估计了 HIV 护理三个阶段中抑郁症状的患病率：尚未接受抗逆转录病毒治疗 (ART) 的患者、最近开始 ART 的患者（开始 ART ≤ 30 天前）和 ART 使用者（开始 ART 前 > 30 天）。通过比较最近的 ART 启动者和 ART 用户来估计抑郁症状的调整患病率差异 (aPD)。披露和性别作为艾滋病毒护理阶段和抑郁症状之间关系的效果测量修正因素进行了检查。尚未接受 ART 的感染者、近期 ART 启动者和 ART 使用者中抑郁症状的患病率分别为 11.9%、22.0% 和 8.7%。与最近的 ART 启动者相比，ART 使用者的抑郁症状患病率显着降低 (aPD - 0.09 [95% CI - 0.11, - 0.08])。性别和艾滋病毒披露都没有改变艾滋病毒护理阶段与抑郁症状之间关系的效果测量。抑郁症状在这组感染者中很常见，并且与最近开始接受抗逆转录病毒治疗有关。 应优先考虑将抑郁症筛查和治疗纳入艾滋病毒护理，这对于感染者启动抗逆转录病毒疗法尤其重要。