Centriole maturation is essential for ciliogenesis, but which proteins and how they regulate ciliary assembly is unclear. In this issue, Kumar et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202011133) shed light on this process by identifying a ciliopathy complex at the distal mother centriole that restrains centriole length and supports the formation of distal appendages.

中文翻译：

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DISCO 是中心粒成功成熟的关键


中心粒成熟对于纤毛发生至关重要，但哪些蛋白质以及它们如何调节纤毛组装尚不清楚。在本期中，库马尔等人。 (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202011133) 通过识别远端母中心粒处的纤毛病复合体来阐明这一过程，该纤毛病复合体限制中心粒长度并支持远端附属物的形成。