Long non-coding RNA (lncRNA) is a newly identified regulator of tumor formation and tumor progression. The function and expression of lncRNAs remain to be fully elucidated, but recent studies have begun to address their importance in human health and disease. The lncRNA, SRA, known as Steroid receptor activator, acts as an important modulator of gynecological cancer, and its expression may affect biological functions including proliferation, apoptosis, steroid formation and muscle developments. However, it is still not well known whether SRA is involved in the regulation of ovarian cancer. This study investigated the molecular function and association between SRA expression and clinicopathological factors. In ovarian cancer cell lines, SRA knockdown and overexpression regulated cell migration, proliferation, and invasion. Both in vivo and in vitro experiments using knockdown and overexpression showed that SRA potently regulated epithelial-mesenchymal transition and NOTCH pathway components. Further, clinical data confirmed that SRA was a significant predictor of overall survival and progression-free survival and patients with ovarian cancer exhibiting high expression of SRA exhibited higher recurrence rates than patients with low SRA expression. In conclusion, this study indicates that SRA has clinical significance as its expression can predict the prognosis of ovarian cancer patients. High expression of the lncRNA SRA is strongly correlated with recurrence-free survival of ovarian cancer patients.

中文翻译：

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LncRNA SRA 通过 NOTCH 信号传导和上皮间质转化介导卵巢癌的细胞迁移、侵袭和进展。


长非编码RNA（lncRNA）是新发现的肿瘤形成和肿瘤进展的调节因子。 lncRNA 的功能和表达仍有待充分阐明，但最近的研究已经开始探讨它们在人类健康和疾病中的重要性。 lncRNA（SRA）被称为类固醇受体激活剂，是妇科癌症的重要调节剂，其表达可能影响增殖、凋亡、类固醇形成和肌肉发育等生物学功能。然而，SRA是否参与卵巢癌的调控尚不清楚。本研究调查了 SRA 表达与临床病理因素之间的分子功能和关联。在卵巢癌细胞系中，SRA 敲低和过度表达可调节细胞迁移、增殖和侵袭。使用敲低和过表达的体内和体外实验均表明，SRA 有效调节上皮间质转化和 NOTCH 通路成分。此外，临床数据证实，SRA 是总生存期和无进展生存期的重要预测因子，并且 SRA 高表达的卵巢癌患者比 SRA 低表达的患者表现出更高的复发率。总之，本研究表明SRA具有临床意义，其表达可以预测卵巢癌患者的预后。 lncRNA SRA的高表达与卵巢癌患者的无复发生存密切相关。