Chemotherapeutic drugs are a known factor that impairs the system of life due to their severe side effects. A more worrying fact is that the patients administered with doxorubicin fall under the risk of cardiotoxicity. The evolution of exploring plant-derived compounds is a possible way to combat health issues in therapeutic applications. Hence, this study focuses on the protective effect of plant-based compound nuciferine (NFN) against doxorubicin-induced cardiotoxicity in both in vitro and in vivo models. In this investigation, nuciferine significantly reduces DOX-mediated cardiotoxicity by mitigating reactive oxygen species, thereby preventing DNA fragmentation, regulating apoptosis genes and reducing the caspase 3/7 levels in vitro. Besides, nuciferine has shown significant protection against DOX-induced cardiac impairment and the upregulation of cardiogenic markers in vivo. The DOX-induced oxidative stress can be mitigated via enhancing the endogenous antioxidants, thereby controlling ROS-mediated apoptosis. In virtue of these potential features, nuciferine can be a budding candidate to address therapeutic needs.

化疗药物是一个已知的因素，由于其严重的副作用会损害生命系统。一个更令人担忧的事实是，服用多柔比星的患者有心脏毒性的风险。探索植物衍生化合物的发展是在治疗应用中解决健康问题的一种可能方法。因此，本研究的重点是在体外和体内模型中，植物基复合荷叶碱 (NFN) 对多柔比星诱导的心脏毒性的保护作用。在这项研究中，nuciferine 通过减轻活性氧物质显着降低 DOX 介导的心脏毒性，从而防止 DNA 片段化、调节细胞凋亡基因和降低体外半胱天冬酶 3/7 水平。除了，nuciferine 已显示出对 DOX 诱导的心脏损伤和体内心源性标志物上调的显着保护作用。DOX 诱导的氧化应激可以通过增强内源性抗氧化剂来缓解，从而控制 ROS 介导的细胞凋亡。凭借这些潜在特征，nuciferine 可以成为满足治疗需求的候选药物。