Coronavirus disease 2019 (COVID-19) may cause myocardial injury and myocarditis, and reports of persistent cardiac pathology after COVID-19 have raised concerns of long-term cardiac consequences. We aimed to assess the presence of abnormal cardiovascular resonance imaging (CMR) findings in patients recovered from moderate-to-severe COVID-19, and its association with markers of disease severity in the acute phase. Fifty-eight (49%) survivors from the prospective COVID MECH study, underwent CMR median 175 [IQR 105-217] days after COVID-19 hospitalization. Abnormal CMR was defined as left ventricular ejection fraction (LVEF) <50% or myocardial scar by late gadolinium enhancement. CMR indices were compared to healthy controls (n = 32), and to circulating biomarkers measured during the index hospitalization. Abnormal CMR was present in 12 (21%) patients, of whom 3 were classified with major pathology (scar and LVEF <50% LVEF <40%). There was no difference in the need of mechanical ventilation, length of hospital stay, and vital signs between patients with vs without abnormal CMR after 6 months. Severe acute respiratory syndrome coronavirus 2 viremia and concentrations of inflammatory biomarkers during the index hospitalization were not associated with persistent CMR pathology. Cardiac troponin T and N-terminal pro-B-type natriuretic peptide concentrations on admission, were higher in patients with CMR pathology, but these associations were not significant after adjusting for demographics and established cardiovascular disease. CMR pathology 6 months after moderate-to-severe COVID-19 was present in 21% of patients and did not correlate with severity of the disease. Cardiovascular biomarkers during COVID-19 were higher in patients with CMR pathology, but with no significant association after adjusting for confounders. COVID MECH Study ClinicalTrials.gov Identifier: NCT04314232

中文翻译：

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因 COVID-19 住院 6 个月后的心脏病理学及其与急性疾病严重程度的关系

2019 年冠状病毒病 (COVID-19) 可能会导致心肌损伤和心肌炎，并且有关 COVID-19 后持续性心脏病的报告引起了人们对长期心脏后果的担忧。我们的目的是评估从中度至重度 COVID-19 康复的患者中是否存在异常心血管磁共振成像 (CMR) 结果，及其与急性期疾病严重程度标志物的关系。前瞻性 COVID MECH 研究中的 58 名 (49%) 幸存者在 COVID-19 住院后中位数 175 [IQR 105-217] 天接受了 CMR。 CMR 异常定义为左心室射血分数 (LVEF) <50% 或晚期钆增强造成心肌疤痕。将 CMR 指数与健康对照 (n = 32) 以及指数住院期间测量的循环生物标志物进行比较。 12 例 (21%) 患者存在 CMR 异常，其中 3 例被分类为主要病理（疤痕和 LVEF <50% LVEF <40%）。 6 个月后，CMR 异常与无异常的患者在机械通气需求、住院时间和生命体征方面没有差异。严重急性呼吸综合征冠状病毒2病毒血症和住院期间炎症生物标志物浓度与持续的CMR病理无关。患有 CMR 病理学的患者入院时心肌肌钙蛋白 T 和 N 末端 B 型利钠肽前体浓度较高，但在调整人口统计数据和确定的心血管疾病后，这些关联并不显着。 21% 的患者在中度至重度 COVID-19 后 6 个月出现 CMR 病理学变化，并且与疾病的严重程度无关。在患有 CMR 病理学的患者中，COVID-19 期间的心血管生物标志物较高，但在调整混杂因素后没有显着关联。 COVID MECH 研究 ClinicalTrials.gov 标识符：NCT04314232