Elevated MICs of Susceptible Anti-Pseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization,Antimicrobial Agents and Chemotherapy

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Elevated MICs of Susceptible Anti-Pseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-08-16 , DOI: 10.1128/aac.01204-21
Christian M Gill ₁ , Elif Aktaş ₂ , Wadha Alfouzan _{3,

4} , Lori Bourassa ₅ , Adrian Brink ₆ , Carey-Ann D Burnham ₇ , Rafael Canton ₈ , Yehuda Carmeli ₉ , Marco Falcone ₁₀ , Carlos Kiffer ₁₁ , Anna Marchese _{12,

13} , Octavio Martinez ₁₄ , Spyros Pournaras ₁₅ , Harald Seifert ₁₆ , Abrar K Thabit ₁₇ , Maria Virginia Villegas ₁₈ , Lars F Westblade ₁₉ , David P Nicolau _{1,

20} ,

Affiliation

Center for Anti-Infective Research & Development, Hartford Hospitalgrid.277313.3, Hartford, Connecticut, USA.
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Clinical Microbiology Laboratory, Istanbul, Turkey.
Laboratory Medicine, Farwaniya Hospital, Ministry of Health, Kuwait City, Kuwait.
Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.
Department of Laboratory Medicine and Pathology, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, National Health Laboratory Services, University of Cape Town, Cape Town, South Africa.
Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Servicio de Microbiologia, Hospital Ramón y Cajal-IRYCIS, Madrid, Spain.
National Institute for Infection Control and Antibiotic Resistance, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Infectious Diseases Division, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Internal Medicine Department and LEMC, Alerta Lab, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil.
Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Clinical Microbiology Unit, San Martino Policlinico Hospital-IRCCS for Oncology and Neuroscience, Genoa, Italy.
Department of Pathology and Microbiology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Laboratory of Clinical Microbiology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Institute for Medical Microbiology, Immunology and Hygiene, University of Colognegrid.6190.e, Cologne, Germany.
Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz Universitygrid.412125.1, Jeddah, Saudi Arabia.
Grupo de Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá, Colombia.
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.
Division of Infectious Diseases, Hartford Hospitalgrid.277313.3, Hartford, Connecticut, USA.

The present study evaluated the in vitro potency of ceftazidime and cefepime amongst carbapenem-resistant Pseudomonas aeruginosa collected as part of a global surveillance program and assessed the pharmacodynamic implications using previously published ...

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