A Framework for Efficient N-Way Interaction Testing in Case/Control Studies With Categorical Data,IEEE Open Journal of Engineering in Medicine and Biology

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A Framework for Efficient N-Way Interaction Testing in Case/Control Studies With Categorical Data
IEEE Open Journal of Engineering in Medicine and Biology ( IF 2.7 ) Pub Date : 2021-07-27 , DOI: 10.1109/ojemb.2021.3100416
Aristos Aristodimou ₁ , Athos Antoniades ₂ , Efthimios Dardiotis ₃ , Eleni Loizidou _{4,

5} , George Spyrou ₆ , Christina Votsi ₇ , Christodoulou Kyproula ₇ , Marios Pantzaris ₈ , Nikolaos Grigoriadis ₉ , Georgios Hadjigeorgiou ₁₀ , Theodoros Kyriakides ₁₁ , Constantinos Pattichi _{1,

12}

Affiliation

Department of Computer ScienceUniversity of Cyprus Nicosia 1678 Cyprus.
Stremble Ventures Ltd. Limassol 59 4042 Cyprus.
Department of Neurology, Faculty of MedicineUniversity of Thessaly Volos 38221 Greece.
Department of Hygiene and EpidemiologyUniversity of Ioannina Ioannina 451 10 Greece.
Institute for BioinnovationBiomedical Sciences Research Center Alexander Fleming, Athens, 16672 Greece.
Bioinformatics Department and Cyprus School of Molecular MedicineCyprus Institute of Neurology and Genetics Nicosia 2371 Cyprus.
Neurogenetics Department and Cyprus School of Molecular MedicineCyprus Institute of Neurology and Genetics Nicosia 2371 Cyprus.
Department of Neurology and Cyprus School of Molecular MedicineCyprus Institute of Neurology and Genetics Nicosia 2371 Cyprus.
Department of Neurology IIAristotle University of Thessaloniki Thessaloniki 541 24 Greece.
Medical SchoolUniversity of Cyprus Nicosia 1678 Cyprus.
Department of Basic and Clinical SciencesMedical School University of Nicosia Nicosia 1678 Cyprus.
Biomedical Engineering Research CentreUniversity of Cyprus Nicosia 1678 Cyprus.

The proposed framework enables the efficient identification of n-Way interactions through quality control, feature selection and the binary encoding of the features.

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