Objective

To investigate the association of maternal body mass index (BMI) and recurrent pregnancy loss (RPL).

Design

Systematic review and meta-analysis.

Setting

Not applicable.

Patient(s)

A total of 3,833 women with RPL and 4,083 women as controls.

Intervention(s)

Studies were identified through a search of PubMed, Embase, Scopus, and Cochrane.

Main Outcome Measure(s)

The primary outcome of interest was RPL using the mean differences in maternal BMI as the predictor variable. The results of the meta-analysis were reported as the mean difference with a 95% confidence interval.

Result(s)

In total, 892 studies were reviewed. Pooled data from 25 studies suggested that the maternal BMI of women with a history of recurrent pregnancy loss was significantly higher than the BMI of controls, mean difference 0.7 kg/m² [95% confidence interval 0.2–1.3].

Conclusion(s)

These findings supported an association between maternal BMI and RPL. Large prospective studies are needed to evaluate the influence of maternal BMI on pregnancy outcomes in women with RPL.

中文翻译：

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母亲体重指数和复发性流产的平均差异：观察性研究的系统评价和荟萃分析

客观的

研究孕妇体重指数（BMI）与复发性流产（RPL）的关系。

设计

系统评价和荟萃分析。

环境

不适用。

耐心）

共有 3,833 名患有 RPL 的女性和 4,083 名女性作为对照。

干预措施

通过搜索 PubMed、Embase、Scopus 和 Cochrane 确定了研究。

主要观察指标）

感兴趣的主要结果是使用母亲 BMI 的平均差异作为预测变量的 RPL。荟萃分析的结果报告为具有 95% 置信区间的平均差异。

结果）

总共审查了 892 项研究。来自 25 项研究的汇总数据表明，有反复流产史女性的母亲 BMI 显着高于对照组，平均差异为 0.7 kg/m ² [95% 置信区间 0.2–1.3]。

结论

这些发现支持母亲 BMI 和 RPL 之间的关联。需要大型前瞻性研究来评估母亲 BMI 对 RPL 女性妊娠结局的影响。