Mild brain lesions do not affect brain volumes in moderate-late preterm infants,European Journal of Paediatric Neurology

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Mild brain lesions do not affect brain volumes in moderate-late preterm infants
European Journal of Paediatric Neurology ( IF 3.1 ) Pub Date : 2021-08-17 , DOI: 10.1016/j.ejpn.2021.08.003
Vivian Boswinkel ₁ , Anouk S Verschuur ₂ , Ingrid M Nijholt ₃ , Jochen A C van Osch ₃ , Jacqueline Nijboer-Oosterveld ₃ , Richard J Beare ₄ , Cornelis H Slump ₅ , Linda S de Vries ₆ , Martijn F Boomsma ₃ , Gerda van Wezel-Meijler ₇

Affiliation

Department of neonatology, Isala Women and Children's Hospital, Dokter van Heesweg 2, 8025, AB, Zwolle, the Netherlands; University Medical Center Utrecht Brain Center, Utrecht University, Heidelberglaan 100, 3584, CX, Utrecht, the Netherlands.
Department of Radiology, Isala, Dokter van Heesweg 2, 8025, AB, Zwolle, the Netherlands; Image Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, the Netherlands.
Department of Radiology, Isala, Dokter van Heesweg 2, 8025, AB, Zwolle, the Netherlands.
Murdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington road, Parkville VIC, 3052, Melbourne, VIC, Australia; Department of Medicine, Monash Medical Centre, Monash University, Wellington road, Clayton VIC, 3800, Melbourne, VIC, Australia.
Department of Robotics and Mechatronics University of Twente, Drienerlolaan 5, 7522, NB, Enschede, the Netherlands.
Department of Neonatology, Wilhelmina Kinderziekenhuis, Lundlaan 6, 3584, EA, Utrecht, the Netherlands.
Department of neonatology, Isala Women and Children's Hospital, Dokter van Heesweg 2, 8025, AB, Zwolle, the Netherlands.

Purpose

It is unknown whether frequently occurring mild brain lesions affect brain volumes in moderate (MP²; 32⁺⁰-33⁺⁶ weeks' gestation) and late (LP³; 34⁺⁰-35⁺⁶ weeks’ gestation) preterm infants. Therefore, we aimed to investigate the effect of mild brain lesions on brain volumes in moderate-late preterm (MLPT⁴) infants and to compare brain volumes between MP and LP infants.

Methods

From August 2017 to November 2019, eligible MLPT infants born at Isala Women and Children's Hospital were enrolled in a prospective cohort study (Brain Imaging in Moderate-late Preterm infants ‘BIMP-study’). MRI was performed around term equivalent age (TEA⁵). MRI scans were assessed for (mild) brain lesions. T2-weighted images were used for automatic segmentation of eight brain structures. Linear regression analysis was performed to compare absolute and relative brain volumes between infants with and without mild brain lesions and between MP and LP infants.

Results

36 MP and 68 LP infants were included. In infants with mild brain lesions, intracranial volume (B = 27.4 cm³, p = 0.02), cerebrospinal fluid (B = 8.78 cm³, p = 0.01) and cerebellar volumes (B = 1.70 cm³, p = 0.03) were significantly larger compared to infants without mild brain lesions. After correction for weight and postmenstrual age at MRI, these volumes were no longer significantly different. LP infants had larger brain volumes than MP infants, but differences were not significant. Relative brain volumes showed no significant differences in both analyses.

Conclusion

Neither having mild brain lesions, nor being born moderate prematurely affected brain volumes at TEA in MLPT infants.

中文翻译：

轻度脑损伤不影响中晚期早产儿的脑容量

目的

尚不清楚频繁发生的轻度脑损伤是否会影响中度（MP ²；32 ⁺⁰ -33 ⁺⁶周妊娠）和晚期（LP ³；34 ⁺⁰ -35 ⁺⁶周妊娠）早产儿的脑容量。因此，我们旨在研究轻度脑损伤对中晚期早产儿 (MLPT ⁴ ) 脑容量的影响，并比较 MP 和 LP 婴儿的脑容量。

方法

2017 年 8 月至 2019 年 11 月，在 Isala 妇女儿童医院出生的符合条件的 MLPT 婴儿被纳入一项前瞻性队列研究（中晚期早产儿脑成像‘BIMP 研究’）。MRI 在足月等效年龄 (TEA ⁵ ) 左右进行。MRI 扫描评估（轻度）脑损伤。T2 加权图像用于自动分割八个大脑结构。进行线性回归分析以比较有和没有轻度脑损伤的婴儿之间以及 MP 和 LP 婴儿之间的绝对和相对脑容量。

结果

包括 36 名 MP 和 68 名 LP 婴儿。在轻度脑损伤的婴儿中，颅内体积（B = 27.4 cm ³，p = 0.02）、脑脊液（B = 8.78 cm ³，p = 0.01）和小脑体积（B = 1.70 cm ³，p = 0.03）显着与没有轻度脑损伤的婴儿相比更大。在 MRI 校正体重和月经后年龄后，这些体积不再有显着差异。LP婴儿的脑容量比MP婴儿大，但差异不显着。在这两种分析中，相对脑容量没有显示出显着差异。