Herein, we describe a method for the synthesis of functionalized quinolines from 2-aminobenzyl alcohols with α,β-unsaturated ketones. This method exhibits tolerance to various functional groups and high efficiency, is environmentally benign, and can be performed on a gram scale. Control experiments suggest that this transformation is accomplished by iridium complex catalyzed transfer hydrogenation, which is then followed by Friedländer cyclization. The results display that alkali is essential for the high selectivities of this catalytic system.

中文翻译：

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铱催化转移加氢从 2-氨基苄醇与水中的烯酮构建喹啉

在此，我们描述了一种从 2-氨基苯甲醇与 α,β-不饱和酮合成功能化喹啉的方法。该方法对各种官能团具有耐受性，效率高，对环境无害，可以在克级规模上进行。对照实验表明，这种转化是通过铱络合物催化的转移氢化，然后是弗里德兰德环化来完成的。结果表明碱对于该催化体系的高选择性是必不可少的。