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Successful lung transplantation with graft recovered after thoracoabdominal normothermic perfusion from donor after circulatory death
American Journal of Transplantation ( IF 8.8 ) Pub Date : 2021-08-17 , DOI: 10.1111/ajt.16806
Marian Urban 1 , Anthony W Castleberry 1 , Nicholas W Markin 2 , Megan M Chacon 2 , Heather M Strah 3 , John Y Um 1 , David Berkheim 1 , Shaheed Merani 4 , Aleem Siddique 1
Affiliation  

Lung transplantation with lungs procured from donors after circulatory death (DCD) has been established as an alternative technique to traditional donation after brain death (DBD) with comparable outcomes. Recently, in situ thoracoabdominal normothermic regional perfusion (TA-NRP) has emerged as a novel technique employed in the procurement of cardiac allografts after circulatory death. TA-NRP, in contrast to ex situ machine perfusion, has the advantage of allowing in situ assessment of donor organs prior to final acceptance. However, there are some concerns that this technique may adversely impact the quality of lung allografts. Here, we present a case of a successful bilateral sequential lung transplantation in a patient with postinflammatory pulmonary fibrosis due to acute respiratory distress syndrome (ARDS), with lungs procured after normothermic in situ lung perfusion. Apart from the lungs, heart, liver, and kidneys were also successfully transplanted from this donor.

中文翻译:

循环死亡后供体胸腹腔常温灌注后肺移植成功,移植物恢复

从循环死亡 (DCD) 后的供体获得的肺进行肺移植已被确定为脑死亡 (DBD) 后传统捐献的替代技术,具有可比的结果。最近,原位胸腹常温区域灌注(TA-NRP)已成为一种新技术,用于在循环死亡后采购心脏同种异体移植物。TA-NRP 与非原位机器灌注相比,具有允许在最终接受之前对供体器官进行原位评估的优势。然而,有人担心这种技术可能会对肺同种异体移植物的质量产生不利影响。在此,我们介绍一例因急性呼吸窘迫综合征 (ARDS) 而导致炎症后肺纤维化的患者成功进行双侧肺移植的案例,常温原位肺灌注后获得的肺。除了肺,心脏、肝脏和肾脏也从这名捐赠者身上成功移植。
更新日期:2021-08-17
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