The abuse of antibiotics is creating a public health crisis and leads to the emergence of drug-resistant bacteria. Short-chain fatty acids (SCFAs) are the ferment products of gut microbiota with carbohydrate and play a pivotal role in host health. To date, there is very limited research on the potential anti-infection effect of SCFAs. In this study, the effects of butyrate on the pathogenicity of Aeromonas hydrophila (A. hydrophila) were investigated. Butyrate at sub-MIC concentrations could reduce the population growth rate of A. hydrophila but did not significantly affect its population at the stationary phase. Butyrate could decrease the production of virulence factors of A. hydrophila in a concentration-dependent manner. Sub-MIC butyrate could inhibit the activity of protease and haemolysin by 62.41% and 56.02% at 1.00 mg ml^−1, respectively, and decrease the biofilm formation of A. hydrophila at 34.71%. In vivo study showed that the sub-MIC butyrate could increase the survival of Caenorhabditis elegans (C. elegans) against A. hydrophila. Furthermore, after challenging with A. hydrophila, the survival rate of zebrafish in butyrate-supplemented group was significantly higher than that of control (p < .05). These results suggested that butyrate could be used as a promising feed additive to protect the host against A. hydrophila infection.

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丁酸盐对嗜水气单胞菌致病性的影响

滥用抗生素正在造成公共卫生危机，并导致耐药细菌的出现。短链脂肪酸 (SCFA) 是肠道微生物群与碳水化合物的发酵产物，在宿主健康中起着关键作用。迄今为止，关于短链脂肪酸潜在抗感染作用的研究非常有限。在这项研究中，对致病丁酸的影响嗜水（一， 水气）进行了调查。亚 MIC 浓度的丁酸盐可以降低A的种群增长率。 嗜水菌，但对静止期的种群数量没有显着影响。丁酸盐可以减少A毒力因子的产生。 嗜水气以依赖浓度的方式。亚 MIC 丁酸盐在 1.00 毫克/毫升¹时可分别抑制蛋白酶和溶血素的活性 62.41% 和 56.02% ，并减少A的生物膜形成。 亲水性为 34.71%。体内实验表明，亚MIC丁酸可以增加生存的秀丽隐杆线虫（Ç。 线虫反对）一个。 嗜水菌。此外，在挑战A 之后。 嗜水气，斑马鱼在丁酸补充组的存活率比对照的显著更高（p < .05）。这些结果表明丁酸盐可以作为一种很有前途的饲料添加剂来保护宿主免受A 的侵害。 嗜水菌感染。