Functions of the SNAI family in chondrocyte-to-osteocyte development,Annals of the New York Academy of Sciences

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Functions of the SNAI family in chondrocyte-to-osteocyte development
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2021-08-17 , DOI: 10.1111/nyas.14668
Ehsan Razmara ₁ , Amirreza Bitaraf ₂ , Behnaz Karimi ₃ , Sadegh Babashah ₂

Affiliation

Different cellular mechanisms contribute to osteocyte development. And while critical roles for members of the zinc finger protein SNAI family (SNAIs) have been discussed in cancer-related models, there are few reviews summarizing their importance for chondrocyte-to-osteocyte development. To help fill this gap, we review the roles of SNAIs in the development of mature osteocytes from chondrocytes, including the regulation of chondro- and osteogenesis through different signaling pathways and in programmed cell death. We also discuss how epigenetic factors—including DNA methylation, histone methylation and acetylation, and noncoding RNAs—contribute differently to both chondrocyte and osteocyte development. To better grasp the important roles of SNAIs in bone development, we also review genotype–phenotype correlations in different animal models. We end with comments about the possible importance of the SNAI family in cartilage/bone development and the potential applications for therapeutic goals.

中文翻译：

SNAI 家族在软骨细胞到骨细胞发育中的功能

不同的细胞机制有助于骨细胞的发育。虽然在癌症相关模型中讨论了锌指蛋白 SNAI 家族 (SNAI) 成员的关键作用，但很少有评论总结它们对软骨细胞到骨细胞发育的重要性。为了帮助填补这一空白，我们回顾了 SNAI 在从软骨细胞发育成熟骨细胞中的作用，包括通过不同的信号通路和程序性细胞死亡调节软骨和成骨。我们还讨论了表观遗传因素（包括 DNA 甲基化、组蛋白甲基化和乙酰化以及非编码 RNA）对软骨细胞和骨细胞发育的不同贡献。为了更好地掌握 SNAI 在骨骼发育中的重要作用，我们还回顾了不同动物模型中基因型 - 表型的相关性。

更新日期：2021-08-17

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