Pancreatic β-cell dysfunction contributes to type 2 diabetes mellitus (T2DM) pathogenesis. However, human islet studies have revealed few consistent molecular changes in T2DM, owing partly to technical and biological confounding factors. A new multi-omics study of islets from well-phenotyped living donors attempts to overcome these limitations to catalogue T2DM-associated molecular changes.

中文翻译：

---

2型糖尿病中β细胞衰竭的多组学路线图

胰腺 β 细胞功能障碍导致 2 型糖尿病 (T2DM) 发病机制。然而，人类胰岛研究显示 T2DM 几乎没有一致的分子变化，部分原因是技术和生物混杂因素。一项新的对来自良好表型活体供体的胰岛的多组学研究试图克服这些限制，对与 T2DM 相关的分子变化进行分类。