Abstract

Polymer and hydroxyapatite (HAP) composites have growing interest in bone regeneration. Commonly used for these applications is polyvinylpyrrolidone (PVP), which represents excellent biological inertness, is biocompatible, and do not adversely interact with HAP. For this reason, in our studies, we have focused on 3-igreedient biocomposites based on PVP/histidine/HAP investigating their mechanical performance, morphology, swelling property and incubation response. The objective is to determine the effect of histidine on the UV cross-linked hydroxyapatite-polymers composites particularly focused on the role of their composition on structure, mechanical properties, and biocompatibility. The results confirm bioactivity of this material and it desirable features for orthopedics.

摘要

聚合物和羟基磷灰石 (HAP) 复合材料对骨再生越来越感兴趣。通常用于这些应用的是聚乙烯吡咯烷酮 (PVP)，它代表了优异的生物惰性、生物相容性，并且不会与 HAP 产生不利的相互作用。出于这个原因，在我们的研究中，我们专注于基于 PVP/组氨酸/HAP 的 3-igreedient 生物复合材料，研究它们的机械性能、形态、溶胀性和孵育响应。目的是确定组氨酸对 UV 交联羟基磷灰石-聚合物复合材料的影响，特别关注其组成对结构、机械性能和生物相容性的作用。结果证实了这种材料的生物活性以及它对骨科的理想特性。