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The fragility of randomized placebo-controlled trials for irritable bowel syndrome
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2021-08-16 , DOI: 10.1111/nmo.14166
MaryJane O Williams 1 , Mary Sedarous 2 , Brittany Dennis 2 , Vanessa Dlamini 3 , Obioma Nwaiwu 4 , Linda Nguyen 5 , Philip N Okafor 5
Affiliation  

The fragility index (FI) represents the number of participants whose status in a trial would have to change from a non-event (not experiencing the primary endpoint) to an event (experiencing the primary endpoint) in order to turn a statistically significant result into a non-significant result. We sought to evaluate the fragility indices of irritable bowel syndrome [IBS-mixed (IBS-M), IBS-constipation (IBS-C), & IBS-diarrhea (IBS-D)] trials.

中文翻译:

肠易激综合征随机安慰剂对照试验的脆弱性

脆弱性指数 (FI) 表示在试验中的状态必须从非事件(未经历主要终点)变为事件(经历主要终点)以便将具有统计学意义的结果转变为的参与者数量一个不显着的结果。我们试图评估肠易激综合征 [IBS-混合 (IBS-M)、IBS-便秘 (IBS-C) 和 IBS-腹泻 (IBS-D)] 试验的脆弱性指数。
更新日期:2021-08-17
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