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Changing epidemiology of liver disease in Asia: Dual infection of HBV and HCV
Liver International ( IF 6.0 ) Pub Date : 2021-08-17 , DOI: 10.1111/liv.15040
Chun-Jen Liu, Pei-Jer Chen

Transmission of hepatitis B virus (HBV) and hepatitis C virus (HCV) is similar regarding the mode of transmission and related risk factors. Therefore, it is not rare to encounter dual HBV/HCV infection in populations at risk of parenteral exposure to hepatitis viruses. Besides, in HBV endemic countries before the era of global HBV vaccination, dual HBV/HCV infection was clinically significant likely because of HCV superinfection over pre-existing HBsAg carriage. Universal childhood HBV vaccination was implemented worldwide since 1992. Public education programs for prevention of new hepatitis viral infections have been actively promoted recently by World Health Organization. Apart from preventive measures, potent anti-HBV agents effective in the control of viral replication have been introduced gradually in the past three decades. Direct acting antiviral agents capable of curing HCV infection in more than 97% of patients with chronic hepatitis C have also been widely implemented in the past decade. These interventions will change the epidemiology of new HBV or HCV mono-infection and dual HBV/HCV infection. Understanding the evolution in the epidemiology of dual HBV/HCV infection is important for evaluation of current public health policy towards infectious disease control in different countries. The changing prevalence of dual HBV/HCV infection in certain Asia-Pacific countries will be re-visited based on endemicity of HBV or HCV, as well as in populations at risk of parenteral viral infection.

中文翻译:

亚洲肝病流行病学的变化:HBV和HCV的双重感染

乙型肝炎病毒 (HBV) 和丙型肝炎病毒 (HCV) 的传播方式和相关危险因素相似。因此,在有肠外暴露于肝炎病毒风险的人群中遇到双重 HBV/HCV 感染的情况并不少见。此外,在全球 HBV 疫苗接种时代之前的 HBV 流行国家中,HBV/HCV 双重感染具有临床意义,可能是因为 HCV 重复感染超过了预先存在的 HBsAg 携带。自 1992 年以来在全球范围内实施了普遍的儿童 HBV 疫苗接种。世界卫生组织最近积极推动了预防新型肝炎病毒感染的公共教育计划。除了预防措施外,在过去的三十年里,还逐渐引入了有效控制病毒复制的强效抗 HBV 药物。在过去十年中,能够治愈超过 97% 的慢性丙型肝炎患者的 HCV 感染的直接作用抗病毒药物也已得到广泛应用。这些干预措施将改变新的 HBV 或 HCV 单一感染和 HBV/HCV 双重感染的流行病学。了解 HBV/HCV 双重感染的流行病学演变对于评估当前针对不同国家传染病控制的公共卫生政策具有重要意义。将根据 HBV 或 HCV 的流行性以及有肠外病毒感染风险的人群重新审视某些亚太国家 HBV/HCV 双重感染的流行率变化。这些干预措施将改变新的 HBV 或 HCV 单一感染和 HBV/HCV 双重感染的流行病学。了解 HBV/HCV 双重感染的流行病学演变对于评估当前针对不同国家传染病控制的公共卫生政策具有重要意义。将根据 HBV 或 HCV 的流行性以及有肠外病毒感染风险的人群重新审视某些亚太国家 HBV/HCV 双重感染的流行率变化。这些干预措施将改变新的 HBV 或 HCV 单一感染和 HBV/HCV 双重感染的流行病学。了解 HBV/HCV 双重感染的流行病学演变对于评估当前针对不同国家传染病控制的公共卫生政策具有重要意义。将根据 HBV 或 HCV 的流行性以及有肠外病毒感染风险的人群重新审视某些亚太国家 HBV/HCV 双重感染的流行率变化。
更新日期:2021-08-17
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